芍药苷治疗创伤后应激障碍的研究进展  

The Progress of Peoniflorin Therapy on Post-traumatic Stress Disorder

作　　者：何立雄[1] 杨凡[2] 梅强[3] 刘运来[4] 

机构地区：[1]第三军医大学学员旅三队,重庆400038 [2]第三军医大学学员旅五队,重庆400038 [3]第三军医大学学员旅四队,重庆400038 [4]第三军医大学基础部组织学与胚胎学教研室,重庆400038

出　　处：《医学综述》2011年第10期1514-1516,共3页Medical Recapitulate

摘　　要：创伤后应激障碍(PTSD)是军人应对突发事件后常见、反复发作的慢性精神障碍,有较高的自杀率与功能损害。由于人们对PTSD有很多误解,所以治疗存在较多困难。近年来,PTSD在神经生物学方面有了更多新发现,芍药苷单体成分具有显著的抗抑郁、抗焦虑和神经保护作用,临床症状完全缓解或大部分消除及功能康复是可期待的。芍药在抗PTSD方面有着广阔的应用前景,有希望将芍药及其有效成分开发成临床效果显著、低毒高效、药效持久的抗PTSD制剂。Post-traumatic stress disorder（PTSD） is a common,recurrent chronic mental disorder which occurs in military who suffers from sudden events,leading to a high frequency of suicide and funtional impairment.As there is much misunderstanding on PTSD,more difficulties are encountered in the treatment.Lately,there are many new discoveries in neurobiology,including peoniflorin monomer′s distinguished effect on anti-depression,anti-anxiety and neural protection.It is very likely that the symptoms will be completely relieved or mostly eliminated and the functional rehabilitation is in the horizon.Paeonia lactiflora pall has a wide application prospect in anti-PTSD field,and the exploration of the effective components and the development of a highly effective preparation with low side-effects and great clinical significance is expected.

关 键 词：创伤后应激障碍 治疗 军事医学 芍药苷 

分 类 号：R285.5[医药卫生—中药学]