激光拉曼光谱在白内障研究中的应用  

The Application of Raman Spectroscopy in Cataract Study

作　　者：方立铭[1] 程桂平[1] 

机构地区：[1]皖南医学院医用物理学教研室,安徽芜湖241002

出　　处：《医学综述》2011年第10期1548-1549,共2页Medical Recapitulate

基　　金：安徽省高等学校省级自然科学基金(KJ2010B251)

摘　　要：激光拉曼光谱技术通过对物质的分子振动-转光谱的检测来识别和区分不同的物质结构,从而可以在分子水平上了解晶状体蛋白的构成及其变化规律。国内外学者利用这一技术检测了多种白内障晶状体的拉曼光谱,通过光谱中氨基酸侧链、巯基、二硫键和酰胺键的谱峰强度和频移变化行为了解白内障形成过程,为防治白内障提供新思路和理论依据。Laser Raman spectroscopy identifies and distinguishes between different physical structures by molecular vibration-rotational spectra,thus to understand the composition of the lens proteins and its variation on the molecular level.Domestic and foreign scholars have used this technology to detect the Raman spectra of various lens cataracts,and the formation process were understood by peak intensity and frequency shift change of amino acid side chain,sulfhydryl,disulfide and amide bond,providing new ideas and theoretical basis for the prevention of cataract.

关 键 词：晶状体 蛋白质 激光拉曼光谱 

分 类 号：O657.37[理学—分析化学] R776.1[理学—化学]