厄贝沙坦联合氢氯噻嗪对原发性高血压患者左心室肥厚的影响  

Effect of Irbesartan and Hydrochlorothiazide on Blood Pressure in Patients with Essential Hypertension and Left Ventricular Hypertrophy

作　　者：张云[1] 梅松柳[1] 郭红霞[1] 

机构地区：[1]牡丹江医学院红旗医院急诊综合内科,黑龙江牡丹江157000

出　　处：《医学综述》2011年第10期1585-1586,共2页Medical Recapitulate

摘　　要：目的观察厄贝沙坦联合氢氯噻嗪对原发性高血压患者左心室肥厚的逆转效果。方法 56例原发性高血压伴左心室肥厚患者随机分成两组,各28例。对照组给予厄贝沙坦150 mg/d,观察组在此基础上加氢氯噻嗪12.5 mg/d,治疗6个月后,观察治疗前后两组患者血压变化,并计算左心室心肌重量(LVM)、左心室重量指数(LVMI)。结果两组患者治疗后收缩压及舒张压与对照组比较差异有统计学意义(P<0.05)。两组患者治疗后LVM、LVMI与对照组比较差异有统计学意义(P<0.05)。两组治疗后血钾水平分别与本组治疗前比较,差异均无统计学意义(P>0.05)。结论厄贝沙坦联合氢氯噻嗪降压以及逆转左心室肥厚的临床效果比单用厄贝沙坦更好。Objective To observe the reversal effect of irbesartan and hydrochlorothiazide on blood pressure in patients with essential hypertension and left ventricular hypertrophy.Methods 56 cases of essential hypertension with left ventricular hypertrophy were randomly divided into two groups,treated with irbesartan 150 mg/d,plus hydrogenation chlorothiazide 12.5 mg/d in the observation group,for 6 months,observed before and after treatment of blood pressure change and calculate left ventricular myocardial weight measurement（LVM）,left ventricular mass index（LVMI）.Results The two groups after treatment compared with those before treatment significantly reduced SBP and DBP,and the observation group was lower than the control group after treatment（P﹤0.05）.LVM,LVMI were significantly lower in both groups of patients after treatment,and the observation group was lower than the control group（P﹤0.05）.No significant difference was observed in serum potassium levels after treatment（P﹥0.05）.Conclusion Irbesartan combined with hydrochlorothiazide effect on lowering the blood pressure and reversing of left ventricular hypertrophy is better than the single-use.

关 键 词：厄贝沙坦 氢氯噻嗪 原发性高血压 左心室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病]