新藤黄酸固体脂质纳米粒在大鼠血浆中的稳定性考察  

Stability of neogambogic acid SLN in rat plasma

作　　者：陈延杰[1] 陈卫东[1] 雷妮[1] 张劲[1] 

机构地区：[1]安徽中医学院药学院,安徽合肥230031

出　　处：《安徽医药》2011年第6期679-680,共2页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省教育厅重点项目(NoKJ2011A190)

摘　　要：目的测定新藤黄酸固体脂质纳米粒(solid lipid nanoparticles,SLN)在大鼠血浆中的稳定性。方法采用高效液相色谱法,通过测定对比新藤黄酸对照品溶液和新藤黄酸SLN在大鼠血浆中的渗漏率,考察新藤黄酸SLN在血浆中的稳定性。结果新藤黄酸对照品溶液的渗漏率为71.2%,新藤黄酸SLN的渗漏率为38.5%。结论表明新藤黄酸SLN相对于对照品溶液,在血浆中稳定。Aim To detect the stability of solid lipid nanoparticle in rat plasma.Methods Through detecting and contrasting the leakage rate of neo-gambogic acid reference solution and neo-gambogic acid SLN by HPLC,the stability of neo-gambogic acid SLN in rat plasma was examined.Results The leakage rate of neo-gambogic acid reference solution was 71.2%,and the neo-gambogic acid SLN was 38.5%.Conclusion Neo-gambogic acid SLN has higher stability than neo-gambogic reference solution.

关 键 词：新藤黄酸 固体脂质纳米粒 渗漏率 稳定性 

分 类 号：R285.5[医药卫生—中药学]