苯妥英钠药物浓度监测指导疗效不佳患者合理用药研究  

Rational drug use in patients with poor efficacy under the monitoring of phenytoinum natricum concentration

作　　者：王晓娟[1,2] 吴成义[1] 袁君[1,2] 陈艳[1] 魏伟[1] 

机构地区：[1]安徽医科大学临床药理研究所,安徽合肥230032 [2]安徽省淮南市第一人民医院,安徽淮南232007

出　　处：《安徽医药》2011年第6期776-778,共3页Anhui Medical and Pharmaceutical Journal

基　　金：淮南市科技计划项目(No200702030)

摘　　要：目的研究如何利用苯妥英钠药物浓度监测指导疗效不佳患者进行合理用药。方法采用反相高效液相色谱法对22例服用苯妥英钠疗效不佳患者进行血中药物浓度监测,制定个体化给药方案,并对结果进行分析。结果依据首次监测结果调整用药方案后,血药浓度合格率及临床有效率分别由之前的22.7%、31.7%提高至70.6%、81.8%。发作频率由4.57次/月下降至2.02次/月。结论对疗效不佳患者进行药物浓度监测,能够提高临床有效率,降低药物不良反应及中毒发生率,提高患者生活质量。Aim To study the use of drug monitoring of phenytoinum natricum concentration in order to guide rational drug use in patients with poor efficacy.Methods Blood concentration of phenytoinum natricum was detected in 22 cases of patients by HPLC.Formulation of the individualized dosing protocol was made and the results were analyzed.Results The conformity rate of blood concentration and clinical efficiency were increased from 22.7%,31.7% to 70.6%,81.8%,respectively,and the frequency was decreased from 4.57 to 2.02 in average each month,according to monitoring results to adjust treatment options.Conclusion By monitoring the concentration of drug in patients,the clinical efficacy rate is increased,drug adverse reaction and incidence rate of intoxation are decreased,and the life quality of patients are improved.

关 键 词：苯妥英钠 药物浓度监测 指导用药 

分 类 号：R96[医药卫生—药理学]