腰椎间盘退变组织中NFκ-B、MMP-1/TIMP-1的表达及意义  

Expression and significance of NF-κB,MMP-1/TIMP-1 in intervertebral disc degeneration

作　　者：原野[1] 赵静[2] 李永民[1] 王旭[1] 

机构地区：[1]唐山市第二医院,河北唐山063000 [2]河北联合大学病理教研室

出　　处：《山东医药》2011年第19期4-5,共2页Shandong Medical Journal

基　　金：河北省教育厅自然科学指导计划项目(Z2005102)

摘　　要：目的探讨NFκ-B、基质金属蛋白酶(MMP)-1基/质金属蛋白酶抑制剂(TIMP)-1表达在椎间盘退变过程中的作用。方法应用免疫组织化学方法和ELISA方法检测38例椎间盘退变所致腰椎间盘突出症患者退变椎间盘髓核组织(观察组)和8例腰椎爆裂骨折患者的正常椎间盘髓核组织(对照组)中NFκ-B、MMP-1、TIMP-1的表达,计算MMP-1与TIMP-1的比值。结果观察组的NFκ-B表达及MMP-1/TIMP-1均明显高于对照组,P均<0.05。结论 NFκ-B、MMP-1/TIMP-1在腰椎间盘退变过程中起重要作用。Objective To investigate the roles of the expression of nuclear factor kappa B（NF-κB）,matrix metalloproteinases-1（MMP-1） and tissue inhibitors of metalloproteinase-1（TIMP-1） in the degeneration of intervertebral disc.Methods Tirty-eight patients with intervertebral disc degeneration from surgical intervention for cervical disc herniation（observed group） and 8 cases of normal disc tissue（control group） were involved,the expression of NF-κB,MMP-1 and TIMP-1 in disc-tissue were tested by immunohistochemistry method and ELISA,the MMP-1/TIMP-1 was calculated.Results The expression of NF-κB,MMP-1/TIMP-1 in observed group were both higher than those in the control group,both P0.05.Conclusion NF-κB and MMP-1/TIMP-1 may have important effects in the process of intervertebral disc degeneration.

关 键 词：腰椎间盘退变 核因子ΚB 基质金属蛋白酶 基质金属蛋白酶抑制剂 

分 类 号：R681.5[医药卫生—骨科学]