脑fMRI观察电针神门及三阴交穴治疗失眠机制  

Cerebral fMRI in observation on the therapeutic mechanism of electro-acupuncture on Shenmen and Sanyinjiao for insomnia

作　　者：周全[1] 杨大艳[1] 崔晓[2] 杨侃荣[1] 李洁[1] 赵仓焕[2] 

机构地区：[1]暨南大学附属第一医院影像中心,广东广州510630 [2]暨南大学附属第一医院针灸科,广东广州510630

出　　处：《中国介入影像与治疗学》2011年第3期204-207,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家中医药管理局中医药留学回国人员科技活动择优项目(国中医药研2006LHR01)

摘　　要：目的利用fMRI技术探讨电针神门、三阴交穴治疗失眠的机制。方法对7名失眠患者(失眠组)及6名健康志愿者(正常对照组)分别在无任何刺激状态下行静息扫描、电针刺激双侧神门和三阴交穴下行BOLD-fMRI扫描,观察两组受试者的激活脑功能区。采用SPM基本模式中的单样本t检验进行统计分析。结果两组受试者均可见脑岛(BA13)明显激活。但在失眠组,右侧丘脑腹前核、右侧壳核、左内侧苍白球、左侧中央前回(BA9)、双侧尾状核头部被特异性地激活。结论电针神门、三阴交穴治疗失眠的机制可能是电针刺激激活了丘脑腹前核、尾状核、壳核、内侧苍白球、丘脑网状核以及其他睡眠中枢,整合传入和传出的信息,调节睡眠;并可通过不同的通路调畅情志,舒缓压力,达到助眠作用。Objective To observe the therapeutic mechanism of electro-acupuncture on Shenmen and Sanyinjiao in treating insomnia with fMRI.Methods Seven insomnia patients（insomnia group） and 6 normal controls（control group） were enrolled.BOLD-fMRI was performed under no stimulation and the status of electro-acupuncture double-side points Shenmen and Sanyinjiao stimulation,respectively.The activation of cerebral functional areas of the two groups were observed.The data were statistically analyzed with one sample t test in a basic model of SPM.Results The insula area（BA13） was activated in both groups.But in the insomnia group,the right thalamus（ventral anterior nucleus）,the right putamen,the left medial globus pallidus,the left precentral gyrus（BA9）,bilateral head of caudate nucleus were specifically activated.Conclusion The therapeutic mechanism of electro-acupuncture on Shenmen and Sanyinjiao in treating insomnia might be that electro-acupuncture activates the thalamus（ventral anterior nucleus）,the caudate,the putamen,the medial globus pallidus,the reticular thalamic nucleus and other parts of sleep center,and then integrates the afferent and efferent message and regulates the sleeping.It can also help people fall asleep by regulating the mood and relieving the pressure through the different ways.

关 键 词：电针 磁共振成像 入睡和睡眠障碍 神门穴 三阴交穴 机制 

分 类 号：R445.2[医药卫生—影像医学与核医学] R245[医药卫生—诊断学]