内源分泌型晚期糖化终末产物受体与2型糖尿病颈动脉内膜中层厚度相关  

The level of endogenous secretory receptor for advanced glycation end-products in type 2 diabetes patients is associated with carotid intima-media thickness

作　　者：林夏鸿[1] 陈晓毓[1] 李希圣[1] 林晖莉[2] 黄子扬[2] 周竟雄[1] 梁波[1] 林如海[1] 吴晓鸿[1] 

机构地区：[1]福建医科大学附属第二医院内分泌科,泉州362000 [2]福建医科大学附属第二医院心血管内科,泉州362000

出　　处：《中华内分泌代谢杂志》2011年第4期320-321,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：福建省泉州市技术研究与开发项目基金（2010Z26）

摘　　要：测定78例2型糖尿病患者颈动脉内膜中层厚度（CIMT）.CIMT正常组血浆内源分泌型晚期糖化终末产物受体（esRAGE）高于CIMT增厚组[（0.257 3±0.1656对0.155 4±0.0701）峭/L,P〈0.01].esRAGE与CIMT负相关r=-0.247,P〈0.05）.Logistic回归分析显示CIMT与esRAGE和高密度脂蛋白胆固醇负相关,与年龄正相关.The carotid initima-media thickness（CIMT）in 78 cases of type 2 diabetic patients was measured.The level of plasma endogenous secretion receptor for advanced glycation end-products（esRAGE）in patients with normal CIMT was higher than those with chickened CIMT[（0.257 3±0.165 6 vs 0.155 4±0.0701）μg/L,P〈0.01].esRAGE was negatively associated with CIMT（r=-0.247,P〈0.05）.Logistic regression analysis showed that CIMT was negatively associated with esRAGE and hish density lipoprotein cholesterol,but was positively associated with age.

关 键 词：糖尿病 内源分泌型晚期糖化终末产物受体 颈动脉内膜中层厚度 动脉硬化 

分 类 号：R587.1[医药卫生—内分泌]