组织工程支架材料生物功能化的研究进展  

Research Advances on the Biofunctionality of Tissue Engineering Scaffolds

作　　者：卢婷利[1] 张宏[1] 王韵晴[1] 惠倩倩[1] 赵雯[1] 

机构地区：[1]西北工业大学生命学院,空间环境模拟技术国、防重点学科实验室,陕西西安710072

出　　处：《材料科学与工程学报》2011年第2期301-307,共7页Journal of Materials Science and Engineering

基　　金：国家自然科学基金资助项目(20872119);陕西省自然科学基金资助项目(2010JM2021)

摘　　要：组织工程的目标之一就是制备出能引导细胞分化并产生具有一定功能再生组织的支架材料,支架材料生物功能化能够有效促进细胞的生物活动,是组织再生的关键。本文从提高支架材料生物功能化入手,说明纳米材料是蛋白和细胞吸附的最佳选择,重点分析了化学改性、引入RGD多肽片断、多肽-聚合物支架及ECM基支架材料四种提高支架材料生物功能化的方法,并对支架材料生物功能化的未来发展趋势进行了展望。The major goal of tissue engineering is to produce the scaffold that can induce cells to adhesion,proliferation and differentiation in its surface,and finally to repair the tissue or make the tissue regeneration.The scaffold biofunctionality is the key issue to the tissue regeneration,which can improve the cell bioactivity.In this paper,we focus on the biofunctionality of scaffold and state the nano-structure is advantage for protein absorption and cell adhesion in the surface of scaffold.Four research methods in enhancing scaffold biofunctionality,such as chemical modification,introducing RGD peptide into the scaffold,peptide-polymer hybrid scaffold,and ECM based protein bioactive scaffold are reviewed in detail.The future development trend in biofunctionality of scaffold is predicted at the end of the article.

关 键 词：组织工程支架 生物功能化 纳米结构 RGD-多肽 ECM蛋白 

分 类 号：Q819[生物学—生物工程]