黄芩苷滴丸成型工艺考察  

Study on formation technology of baicalin dropping pills

作　　者：王玉秀[1] 贾金萍[2] 陈大为[3] 秦雪梅[2] 王玉璧[1] 

机构地区：[1]山西生物应用职业技术学院,山西太原030031 [2]山西大学中医药现代研究中心,山西太原030006 [3]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医院药学杂志》2011年第10期837-839,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究黄芩苷滴丸的制备工艺。方法:以滴丸的圆整度、滴制时的拖尾情况、溶散时限、硬度等为指标,对基质、药物与基质的配比、熔融的温度、滴制温度、冷却剂、冷却温度及冷凝柱的长度进行考察。结果:滴丸最佳制备工艺为最佳基质PEG 6000,药(黄芩苷-PVPK30固体分散体)-基质(质量比)(1∶5),熔融温度为80～90℃,滴制温度为85～90℃,冷凝剂为液体石蜡和植物油1∶1的混合物,冷凝液的温度在10℃左右,冷凝柱长为40 cm。结论:优选得到的黄芩苷滴丸成型工艺稳定可行。OBJECTIVE To study on the preparation technology of baicalin dropping pills. METHODS Solid dispersion（SD） of baicalin was prepared with PVPk30. baicalin dropping pills were prepared by dropping method. On the basis of single-factor optimization methods , preparation conditions were selected among sort of matrix , consumption of matrix, the temperature of drug melting, temperature and height of refrigerants and all the procedures were evaluated by the hardness, tailing, scatter time and sphericity of the pills. RESULTS The results showed PEG 6000 was used as matrix. , the ratio of baicalin-PVPk30 solid dispersion to PEG6000 was 1：5 , the refrigerant was liquid paraffin and vegetable oil （condensing agent 1 ： 1 ）, the melting temperature was 80 90 ℃, the mixture was incubated at 85-90 ℃ and dropped into the refrigerant with the height was 40 cm. CONCLUSION The formation and quality of baicalin dropping pills prepared with this technology were better.

关 键 词：黄芩苷 固体分散体 滴丸 成型工艺 

分 类 号：R944.9[医药卫生—药剂学]