伊班膦酸钠治疗肺癌骨转移性疼痛的临床观察  

Clinical study of ibandronate in relieving bone-pain in lung tumour patients with bone metastasis

作　　者：顾玉红[1] 杜佳新[2] 

机构地区：[1]哈尔滨医科大学附属第三医院,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《中国医院药学杂志》2011年第10期846-848,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:评价伊班膦酸钠治疗肺癌骨转移性骨痛的效果。方法:将48例肺癌骨转移骨痛的患者,采用随机方法,分为治疗(A)组:给予重酒石酸长春瑞滨注射液+顺铂注射液(NVB 25 mg·m-2 d1,8+DDP 25 mg·m-2d1-3)即(NP方案)+伊班膦酸钠4 mg;对照(B)组:采用NP方案;观察3个周期,评价止痛效果。结果:A组止痛总有效率为83.3%,B组止痛总有效率为41.7%。A组疗效明显优于B组。结论:伊班膦酸钠可有效治疗肺癌骨转移引起的疼痛,且不良反应小。OBJECTIVE To evaluate the efficacy of ibandronate in relieving bone-pain in lung tumour patients with bone metastasis. METHODS 48 lung tumour patients With bone metastasis bone pain were randomLy divided into group .hi ： treated with NP cure project （vinorehine bitartrate injection ＋ cisplatin injection （NVB 25 mg·m-2d1,8 ＋ DDPA 25 mg·m 2dl-3）） ＋ Ibandronate 4mg,and group B treated with NP cure project ; observation was performed by 3 cycles, to evaluate the efficacy of relieving bone-pain. RESULTS The result showed that the pain remission rate of treatment for group A was 83.3% , and for group B was 41.7%. The efficacy of group A was obviously better than group B. CONCLUSION Ibandronate is effective in bone-pain relief and with less toxic effects.

关 键 词：伊班膦酸钠 肺癌 骨转移 疼痛 

分 类 号：R979.1[医药卫生—药品]