大孔树脂对赤芍总苷吸附的初步研究  

Research on Adsorption of Total Paeony Glycoside with Macroporous Resins

作　　者：陈立江[1] 段洪云[1] 张胜[2] 刘玉峰[1] 李丽[1] 刘洋[1] 

机构地区：[1]辽宁大学药学院,沈阳110036 [2]辽宁省药物研究院,沈阳110015

出　　处：《中国现代应用药学》2011年第5期458-462,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：辽宁省自然科学基金(20092015);沈阳市科学技术计划项目(F10-205-1-28);辽宁大学"211工程"三期建设项目-天然产物化学制药项目的资助

摘　　要：目的研究D101、X-5、HPD-722、HP-20、AB-8、DM-130、HPD-600、NKA-9大孔树脂对赤芍总苷的吸附性能。方法以芍药苷和芍药内酯苷为考察指标,通过静态吸附及解析实验,动态吸附和解析实验,对大孔树脂纯化赤芍总苷的工艺进行筛选。结果 AB-8大孔树脂对芍药苷和芍药内酯苷的比吸附量分别为42.23,53.70 mg·mL-1,比解析量分别为32.19,33.75 mg·mL-1。结论 AB-8大孔树脂的对赤芍总苷的分离纯化效果较好,具有良好的应用前景。OBJECTIVE To investigate the adsorption of total paeony glycoside by D101,X-5,HPD-722,HP-20,AB-8,DM-130,HPD-600,NKA-9.METHODS Through static adsorption and desorption as well as dynamic adsorption and desorption,the purification of total paeony glycoside by AB-8 macroporous resin was selected with paeoniflorin and albiflorin as investigation targets.RESULTS The adsorption quantity of AB-8 resin for paeoniflorin and albiflorin was 42.23,53.70 mg·mL-1,and desorption quantity was 32.19,33.75 mg·mL-1.CONCLUSION The isolation and purification capability of AB-8 macroporous resin is the best in the eight kinds of macroporous resins and have a favourable application perspective.

关 键 词：大孔树脂 芍药苷 芍药内酯苷 吸附 解吸 

分 类 号：R284.2[医药卫生—中药学]