注射用复方葛根素粉针中葛根素在Beagle犬体内药动学研究  

Pharmacokinetic Study of Puerarin from Compound Puerarin Injection in Beagle Dogs In-vivo

作　　者：李耿[1] 吴燕红[2] 彭绍忠[1] 蔡大可[1] 胡家敏[1] 赖小平[1] 苏子仁[1] 

机构地区：[1]广州中医药大学中药学院,广州510006 [2]广东药学院中药学院,广州510006

出　　处：《中药新药与临床药理》2011年第3期307-310,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广州市科技攻关计划重点项目(2007Z3-E5141)

摘　　要：目的研究注射用复方葛根素粉针中葛根素在Beagle犬体内药动学。方法建立快速敏感的高效液相色谱检测方法测定Beagle犬血中葛根素,以6只Beagle犬交叉注射给药,药-时曲线数据经3P97药动学计算程序处理。结果葛根素的药-时过程符合二室模型,葛根素注射液犬体内葛根素的t1/2α=3.111±2.166 h,t1/2β=54.946±32.475 h,AUC0-t=2228.292±1363.136 mg.h-1.L-1;注射用复方葛根素粉针犬体内葛根素的t1/2α=3.752±0.572 h,t1/2β=56.247±3.112 h,AUC0-t=2361.020±109.238 mg.h-1.L-1,结果表明,两者药动学过程没有统计学差异。结论注射用复方葛根素粉针中葛根素与牛磺酸配伍对葛根素的体内药动学无影响。Objective To study the pharmacokinetics of puerarin from Compound Puerarin Injection in Beagle dogs in vivo.Methods The rapid and sensitive HPLC method was adopted to determine the serum puerarin concentration in 6 Beagle dogs.Cross-experiments were carried out in 6 Beagle dogs,and the data of concentration-time profiles were processed by using 3P97 pharmacokinetic program software.Results The concentration-time profiles of puerarin were shown to fit the two-compartment model.The pharmacokinetic parameters of puerarin in dogs treated with puerarin injection were t1/2α=3.111±2.166 h,t1/2β=54.946±32.475 h,AUC0-t=2228.292±1363.136 mg·h-1·L-1.The pharmacokinetic parameters of puerarin in dogs treated with Compound Puerarin Injection were t1/2α=3.752±0.572 h,t1/2β=56.247±3.112 h,AUC0-t=2361.020±109.238 mg·h-1·L-1.There were no significant differences of pharmacokinetic parameters between puerarin injection and Compound Puerarin Injection.Conclusion Compound Puerarin Injection,which is composed of puerarin and taurine,has no effect on puerarin pharmacokinetics in vivo.

关 键 词：注射用复方葛根素粉针 BEAGLE犬 药物动力学 

分 类 号：R285.5[医药卫生—中药学]