水通道蛋白1与恶性肿瘤转移的研究进展  

Progress on relationship between aquaporin-1 and malignant tumor metastasis

作　　者：张伟[1] 姚帅[1] 

机构地区：[1]泰安市中心医院呼吸科,271000

出　　处：《国际呼吸杂志》2011年第10期773-776,共4页International Journal of Respiration

摘　　要：目前哺乳类动物组织中已鉴定出13种水通道蛋白（AQP）,已证实AQP1的功能主要与液体转运有关.最近研究发现AQP1不仅能够促进肿瘤血管生成,而且通过促进迁移细胞伪足上的水运输来促进细胞迁移.大量研究表明AQP1表达与恶性肿瘤转移有关,但AQP1参与恶性肿瘤生长及转移的具体机制尚不明确.本文就AQP1在体内的分布、功能及与恶性肿瘤转移的关系作一综述.At present,thirteen species of aquaporin （AQP） has been identified in mammalian tissues. It is confirmed that AQP1 is mainly related with the fluid transport. Recent studies have found that AQP1 can not only promote tumor angiogenesis,but also promote cell migration through facilitating water transportation in the pseudopodia of migrating cells. A large number of studies have shown that AQP1 expression is related with tumor metastasis,but the exact mechanism is unclear. This paper reviews the distribution,function,and relationship with malignant tumor of AQP1 in tissue.

关 键 词：水通道蛋白1 恶性肿瘤 血管生成 细胞迁移 

分 类 号：R285.5[医药卫生—中药学]