汞对小鼠免疫功能和某些酶的影响  

Studies of Immunotoxicity of Mercurials in Mice

作　　者：向维君[1] 王泽甫[1] 王桂华[1] 廖向东[1] 

机构地区：[1]四川省劳动卫生职业病防治研究所

出　　处：《卫生毒理学杂志》1990年第2期86-88,共3页Journal of Health Toxicology

摘　　要：采用免疫毒理学方法,研究了汞对NIH纯系小鼠免疫功能和某些酶的影响。HgCl_2和CH_3HgCl染毒的各剂量组脾重量、腹腔巨噬细胞吞噬功能、外周血液T淋巴细胞计数、中性粒细胞均低于对按组。CH_3HgCl染毒的3个剂量组和HgCl_2中、高剂量组WBC总数低于对照组。CH_3HgCl、HgCl_2染毒的各剂量组动物肝、肾细胞中酶活性有改变。The immunotoxicity of mercurials was studied in NIH mice received 0.602, 1.81, 5.42mg/kg of mercuric chloride, and fecived 0.363. 1.088. 3.264mg/kg of methyl mercuric chloride orally for 20 days. every other day.Tne results, the spleen weight, WBC total and the count of T lymphocytes in mice tail blood as well as phogocytic function of peritioneal macrophage in eacb treated group were significantly lower than subjects in control; The histopathological and en zyme-histochemical observation showed that epithelial cell of proximal tubles of kidneys and hepatocytes were damaged.

关 键 词：免疫毒性 汞中毒 毒性 

分 类 号：R598.120.2[医药卫生—内科学]