大蒜中有机硫化物抗肿瘤的研究进展  

Advance in antitumor of garlic vegetable-derived organosulfur compounds

作　　者：陈敏[1] 李逐波[1] 

机构地区：[1]西南大学药学院,重庆400716

出　　处：《生命科学》2011年第5期487-491,共5页Chinese Bulletin of Life Sciences

基　　金：重庆市科委攻关项目(2008AA1001)

摘　　要：大蒜是一种古老的药用植物,具有广谱的抗肿瘤作用,发挥其主要抗肿瘤作用的是多种烯丙基有机硫化物。从大蒜中有机硫化物调节致癌物的代谢、抑制肿瘤细胞周期、诱导肿瘤细胞凋亡、消除自由基和抗氧化等方面,对其抗肿瘤作用机制研究进展作一综述。Garlic is an antiquity as medicine,it was proved by epidemiological observations and laboratory studies that garlic and its constituents possessed broad spectrum antitumor effects.But the protective effects of garlic are related to the presence of organosulfur compounds such as allyl derivatives.The antitumor mechanisms of garlic vegetable-derived organosulfur compounds mainly included,modulation of carcinogen metabolism,inhibition of cell cycle progression,induction of apoptosis,free-radical scavenging and oxidation resistance.The advances in the antitumor mechanism of garlic vegetable-derived organosulfur compounds are described in the following review.

关 键 词：大蒜 有机硫化物 抗肿瘤 

分 类 号：S663.4[农业科学—果树学] R285[农业科学—园艺学]