黏合法吻合人造血管和中等动脉的实验研究  

Experimental Study of Arterio-prosthetic Graft Anastomosis by Medical Adhesive

作　　者：刘自豪[1] 梁向党[1] 孙赓[2] 胡波[1] 郝永玉[1] 张虹 

机构地区：[1]解放军总医院骨科医院 [2]解放军252医院 [3]61541部队门诊部

出　　处：《医疗卫生装备》2011年第5期26-27,共2页Chinese Medical Equipment Journal

基　　金：全军医药卫生科研基金项目(08G123)

摘　　要：目的:从生物力学角度探讨黏合法吻合人造血管和中等动脉的可行性。方法:杂种犬离体颈总动脉30根,相对应口径的Gore-Tex ePTFE人造血管若干,医用吻合胶。3种不同吻合方法:传统缝合法、直接黏合法和生物被膜黏合法,比较吻合口抗拉强度的变化。结果:传统缝合法和生物被膜黏合法的抗拉强度都显著高于直接黏合法(P<0.01),传统缝合法和生物被膜黏合法的抗拉强度没有显著差异(P>0.05)。直接黏合法和生物被膜黏合法的吻合完成时间显著快于传统缝合法(P<0.01)。结论:被膜黏合法吻合人造血管和中等动脉的速度优于传统缝合法,抗拉强度也令人满意,是一种具有临床应用前景的吻合方法,但仍需要进一步进行动物体内实验研究。Objective To evaluate the reliability of end-to-end canine carotid arterio-prosthetic graft anastomosis by medical adhesive.Methods The study was divided into three groups.In group 1,ten canine carotid arteries and vascular prostheses were anastomosed by conventional suture;in group 2,ten canine carotid arteries and vascular prostheses were anastomosed in an end-to-end fashion by medical adhesive;in group 3,ten canine carotid arteries and vascular prostheses were anastomosed by medical adhesive alone with bio-membrane.After anastomosis,the tensile strength was measured and the time required was recorded.Results The tensile strength of group 1 and group 3 was higher than that of group 2（p0.01）,and there was no significant difference between group 1 and group 3（p0.05）.The time required for suture-less anastomosis was significantly less than that of suture group（p0.01）.Conclusion The arterio-prosthetic graft anastomosis by medical adhesive alone with bio-membrane shortened the time of anastomosis,and increased the reliability of cohesive anastomosis in vitro study.But further experimental study on the animal was still required.

关 键 词：黏合 吻合 抗拉强度 动脉 

分 类 号：R318.01[医药卫生—生物医学工程]