低浓度苯对小鼠细胞免疫毒性研究  

Study on Cell-mediated Immune Response in Mice Exposed to Benzene of Low Concentration

作　　者：尹秀琴 贾红云[1] 薛晓红 

机构地区：[1]宁夏医学院预防医学系

出　　处：《卫生毒理学杂志》1990年第4期219-220,224,共3页Journal of Health Toxicology

摘　　要：25和50ppm的苯可使小鼠的脾脏和胸腺重量明显降低;外周血T淋巴细胞数明显减少;迟发型变态反应受到抑制;小鼠足垫肿胀部位单核细胞浸润明显少于对照组。15ppm苯即可引起T淋巴细胞数下降。提示苯是一种免疫抑制剂。A series of immune functions were studied in female Kongming mice foliowing a 14-day( 3hr/ day ) inhalation exposure of 6ppm, 15ppm, 25Ppm or 50PPm of benzene. Examined immune para meters included weight of lymPhoid organs ( spleen and thymus ) , the Percentage of T lymphocyte in Peripheral blood, delayed type hypersensitivity to bovine serum albumin. These Parameters were changed when mice were exposed to 25PPm or50Oppm of benzene. The Percentage of T lymphocyte in Peripheral blood was decreased in mice foliowing 14 days exposure of 15ppm of benzene, The results indicate that benzene is an immunosuppremant.

关 键 词：苯 淋巴细胞 免疫 毒性 

分 类 号：R114[医药卫生—卫生毒理学]