依普拉封片溶出度测定方法的研究  

Study on Dissolution Determination Method of Iprilavonl Tablets

作　　者：赵亚萍 胡洪涛 

机构地区：[1]湖北省药品检验所,武汉430064

出　　处：《天津药学》1999年第3期57-59,共3页Tianjin Pharmacy

摘　　要：采用溶出度测定法第二法对依普拉封片进行溶出度测定。以0．9％的十二烷基硫酸钠为溶剂，转速为10or／min，溶出后，采用乙醇为溶剂的紫外分光光度法测定其溶出量并采用对照品法计算。检测波长299nm，浓度范围为2.9～20．3μg／ml。回归方程：A＝0．0431C＋7．14×10(-4)，相关系数：r＝0．9998，平均回收率99．9％（n＝5），RSD＝0．80％，规定45分钟的海出量不低于标示量的70％。This Paper reports the dissolution test (Secondary method) of Ipriflavoni Tablets. Sodium lauryl sulfate (con. 0. 9% ) was used as the dissolution medium, the rotating velocity was 100r/min . The ab sorbance was measured by spectrophotometw at 299nm with ethanol as the dissolution medium. Standard reference method was adopted. A linear standard curve was obtained over the concentration rang from 2. 9 - 20. 3μg/ml, regression equation: A = 0. 0431 C + 7. 14 × 10-4, of which r = 0. 9998, average recovery was 99. 9% and relative standard deviation (RSD) was 0. 8% (n = 5). The drug dissolution rate for 45 min was not less than 70% of the lbeled amount.

关 键 词：依普拉封片 溶出度 紫外分光光度法 对照品法 

分 类 号：R977[医药卫生—药品]