TLR2、TLR4在特发性胎儿生长受限患者胎盘组织的表达及意义  

Expression and significance of toll-like receptor 2 and toll-like receptor 4 in placenta of idiopathic fetal growth restriction

作　　者：崔世红[1] 田燕妮[1] 许雅娟[1] 程国梅[1] 霍会蚕[1] 蔡一鸣[2] 

机构地区：[1]郑州大学第三附属医院妇产科,郑州450052 [2]新乡医学院

出　　处：《现代妇产科进展》2011年第4期262-264,共3页Progress in Obstetrics and Gynecology

基　　金：河南省教育厅科技攻关基金项目(No:2010A320021)

摘　　要：目的：探讨特发性胎儿生长受限（IFGR）胎盘组织中Toll样受体2（TLR2）、Toll样受体4（TLR4）的表达及意义，讨论IFGR的可能病因及发病机制。方法：选取我院2009年6月～2010年4月剖宫产分娩的IFGR孕妇30例为实验组，剖宫产分娩的正常足月孕妇30例为对照组。用免疫组化法检测胎盘组织TLR2、TLR4的表达水平。结果：（1）实验组及对照组的胎盘组织中均有TLR2、TLR4蛋白不同程度的阳性表达；（2）实验组TLR2、TLR4在胎盘合体滋养细胞上的表达高于对照组，差异有统计学意义（P〈0．05）。结论：胎盘组织中TLR2、TLR4表达增加促使了IFGR的发生，可能是IFGR发病机制中的关键环节之一，为临床上应用免疫干预手段预防或治疗IFGR提供了依据。Objective：To investigate the expression and significance of toll-like recep- tor 2 （ TLR2 ） and toll-like receptor 4 （ TLR4 ） in placenta of idiopathic fetal growth restriction （IFGR）, to explore the possible etiology and pathogenesis of IFGR. Methods ：30 cases of preg- nant women with IFGR underwent cesarean section in our hospital from June. 2009 to April. 2010 as the experimental group and 30 cases of normal term pregnant women because of social factors received terminating cesarean section as the control group at the same period. The ex- pression levels of placenta TLR2 and TLR4 were detected with immunohistochemistry. Results： （ 1 ） The positive expressions of TLR2 and TLR4 with different levels were observed in placenta of the two groups. （2） In experimental group, the expression of TLR2 and TLR4 in syncytiotro- phoblast cells were significantly higher than those of the control group, （ P 〈 0.05 ）. Conclu- sion： （ 1 ） The causes of IFGR were related with the increased expression of TLR2 and TLR4 in placental tissues and they may be one of the key pathogenesis of IFGR. （2） It provides basis for the proper prevention or cure of IFGR using the immune intervention therapies in clinic.

关 键 词：特发性胎儿生长受限 TLR2 TLR4 

分 类 号：R714.51[医药卫生—妇产科学]