输卵管积水抽吸术在体外受精-胚胎移植中的意义  

Significance of hydrosalpinx aspiration on patients with hydrosalpinx undergoing in vitro fertilization embryo transfer

作　　者：王媛媛[1] 刘风华[1] 张伟良[1] 黄青[1] 许海燕[1] 杜红姿[1] 石宇[1] 

机构地区：[1]广州医学院第三附属医院广州市妇产科研究所生殖中心,广州510150

出　　处：《现代妇产科进展》2011年第4期279-282,共4页Progress in Obstetrics and Gynecology

摘　　要：目的：评价输卵管积水抽吸术在输卵管积水患者行体外受精-胚胎移植（IVF-ET）中的意义。方法：回顾性分析2005年1月～2009年12月在广州医学院第三附属医院生殖中心因输卵管因素不孕症行IVF-ET治疗的患者资料1029例（1190个周期），分为输卵管积水抽吸组（A组）75例（88个周期）、输卵管积水组（B组）49例（60个周期）和双侧输卵管阻塞组（C组）905例（1042个周期）。结果：3组患者Gn总量、超排天数、移植胚胎数、冷冻胚胎数差异均无统计学意义（P〉0．05）。3组间受精率、胚胎种植率、移植取消率、临床妊娠率、多胎妊娠率、中晚期流产率、异位妊娠率差异均无统计学意义（P〉0．0167）。A、B两组HCG日直径〉12mm的卵泡数、获卵数均少于C组（P〈0．05），A、B两组差异无统计学意义（P〉0．05）；A组生化妊娠率、早期流产率高于C组（P〈0．0167），B、C组差异无统计学意义（P〉0．0167）。结论：取卵时经阴道输卵管积水抽吸术没有改变输卵管积水患者临床妊娠率低、早期流产率高的结局。Objective：To investigate the significance of hydrosalpinx aspiration on pa-tients with hydrosalpinx undergoing in vitro fertilization embryo transfer（IVF-ET）. Methods ：A retrospective analysis was conducted in 1029 patients （1190 cycles） who under went IVF-ET with tubal diseases in the Reproductive Medical Center of Third Affiliated Hospital of Guang- zhou Medical College from Jan. 2005 to Dec. 2009. The patients were divided into three groups： hydrosalpinx aspiration group （ group A） which consisted of 75 patients （ 88 cycles）, hydrosalpinx group （ group B） which consisted of 49 patients （60 cycles） and bilateral salpingemphraxis group （group C）which consisted of 905 patients （1042 cycles）. Results： There was no significant difference among three groups with regard to the total amount of gonadotropin injection,amount of days of controled ovary hyperstimulation and numbers of embryo transfer and frozen （P〉 0.05 ）. There was no significant difference among three groups with regard to the fertilization rate, implantation rate, embryo transfer cancellation rate, clinical pregnancy rate, multiplets pregnancy rate,after first trimester abortion rate and ectopic pregnancy rate（P〉0. 0167）. The numbers of follicles greater than 12mm on the day of HCG, numbers of oocytes aspirated in group A and group B were significantly less than the numbers in group C （P〈0.05）, there was no significant difference between group A and group B （P〉0.05）. The biochemical pregnancy rate and first trimester abortion rate in group A were significantly higher than that in group C （P 〈0. 0167）, there was no significant difference between group B and group C （P〉0. 0167）.Conclusions ：The transvaginal ultrasound-guided hydrosalpinx aspiration during oocyte collection can not change the fact that patients with hydrosalpinx undergoing IVF-ET have the lower clinical pregnancy rate and higher first trimester abortion rate.

关 键 词：输卵管积水 体外受精 胚胎移植 抽吸术 临床妊娠率 早期流产率 

分 类 号：R711.76[医药卫生—妇产科学]