早发严重冠状动脉三支病变患者冠心病危险因素的分布及聚集  

Distribution of Risk Factors for Premature Severe Three-Vessel Coronary Disease

作　　者：牛海芳[1] 车京津[2] 邵元霞[1] 甘慧敏[1] 

机构地区：[1]天津医科大学研究生院,300070 [2]天津医科大学第二医院心内科

出　　处：《天津医药》2011年第5期402-405,共4页Tianjin Medical Journal

摘　　要：目的:探讨早发严重冠脉三支病变患者已知冠心病(CHD)危险因素的分布及聚集。方法:对比早发严重冠脉三支病变患者(CHD组)113例与冠脉正常患者(对照组)57例的临床资料,筛选早发严重冠脉三支病变的危险因素并分析其聚集情况。结果:(1)2组间性别、吸烟史、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、体质量指数(BMI)、高血压病(EH)、糖尿病(DM)、CHD家族史差异有统计学意义(P<0.05或P<0.01)。多元Logistic回归分析显示早发严重冠脉三支病变的危险因素有男性、CHD家族史、DM和高TG血症。(2)CHD组较对照组3种以上危险因素聚集程度明显增加。(3)按性别行亚组分析显示男性CHD与对照2组间吸烟史、CHD家族史、BMI、HDL-C差异有统计学意义(P<0.05),女性CHD与对照2组间DM、EH、TG、HDL-C差异有统计学意义(P<0.05或P<0.01)。结论:男性、CHD家族史、DM、高TG血症是早发严重冠脉三支病变的危险因素,且此类患者存在多种危险因素聚集现象。男女间CHD危险因素存在差异。Objective：To investigate the distribution of known risk factors of coronary heart disease（CHD） for premature severe three-vessel coronary artery lesions.Methods：Clinical data from 113 patients with severe three-vessel coronary artery lesions（CHD group） and 57 patients with normal coronary artery（control group） were collected in this study.The distribution of risk factors were analyzed.Results：（1）There were significant differences in gender,smoking history,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,body mass index（BMI）,essential hypertension（EH）,diabetes mellitus（DM） and positive family history（PFH） of CHD between groups（P﹤0.05 or P﹤0.01）.Multiple logistic regression analysis showed that risk factors for premature three-vessel coronary lesions were male,PFH,DM and hypertriglyceridemia.（2）Compared with the control group,the degree of aggregation significantly increased in 3 or more risk factors in CHD group.（3）Subgroup analysis indicated that smoking,PFH,BMI and HDL-C were significantly different between male patients of two groups（P﹤0.05 or P﹤0.01）.And there were significant differences in DM,EH,TG and HDL-C between female patients of two groups（P﹤0.05 or P﹤0.01）.Conclusion：The risk factors for premature severe three-vessel coronary artery lesions were male,PFH,DM and hypertriglyceridemia,and the aggregation of the main risk factors existed.Risk factors were remarkably different between men and women.

关 键 词：冠心病 危险因素 性别因素 脂类 发病年龄 糖尿病 LOGISTIC模型 

分 类 号：R541.4[医药卫生—心血管疾病]