术前应用氟比洛芬酯与阿扎司琼对小儿斜视矫正术术后疼痛及呕吐的影响  

Effect of preoperative administration of flurbiprofen axetil combined with azasetron on postoperative pain and nausea and vomiting in children undergoing strabismus surgery

作　　者：陈樱[1] 沈卫华[1] 陈倩茹[1] 

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,广州510060

出　　处：《中国实用眼科杂志》2011年第5期442-444,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的 观察术前联合应用氟比洛芬酯与阿扎司琼对小儿斜视矫正术术后疼痛及恶心呕吐的影响.方法 临床病例对照研究.选择中山大学中山眼科中心就诊的60例按美国麻醉医师协会（ASA）标准的Ⅰ～Ⅱ级、年龄8～14岁、择期行斜视矫正术的患儿,均采用异丙酚、芬太尼及阿曲库胺全凭静脉麻醉,根据诱导前辅助用药的不同随机分为3组（n=20）：FA组静脉推注氟比洛芬酯1mg/kg＋阿扎司琼0.2mg/kg;F组给予氟比洛芬酯1mg/kg＋等量生理盐水;A组给予阿扎司琼0.2mg/kg＋等量生理盐水,均在诱导前10min静脉注射.观察术前、术始、术毕、术后各时点的镇痛评分（VAS）及血糖变化,并观察各组苏醒期躁动、术后咽喉部疼痛及恶心、呕吐等不良反应发生情况.结果 FA组和F组术后V.AS评分显著低于A组（P〈0.05）,术后各时点A组血糖水平明显高于FA组和F组（P〈0.05）,FA组和A组术后恶心呕吐发生率明显低于F组（P〈0.05）.结论 术前氟比洛芬酯与阿扎司琼联合应用于小儿斜视矫正术既可明显改善术后疼痛又能减少恶心呕吐等不良反应.Objective To study the effect of preoperative flurbiprofen axetil combined with azasetron on postoperative pain and nausea and vomiting in children undergoing strabismus surgery. Methods A total of 60 children, ASA Ⅰ -Ⅱ, aged 8-14, scheduled for strabismus surgery with total intravenous general anesthesia were randomly assigned to 3 groups（n=20）. In group FA, flurbiprofen axetil（1mg/kg）combined with azasetron（0.2mg/kg）was intravenously injected; only flurbiprofen axetil（1mg/kg）was give in group F and only azasetron（0.2mg/kg）was injected in group A. The above drugs were all administered 10 min before the anesthetic induction. VAS scores and glucose at the end of surgery and after surgery were recorded individually.The incidence rate of restless, nausea and vomiting after surgery were recorded. Results The incidence rate of pain in group FA and group F were significantly lower than that in group A（P 〈0.05）. The postoperative glucose in group A were significantly higher than that in group FA and group F（P 〈0.05）. The incidence rate of nausea and vomiting in group FA and group A were significantly lower compared with group F（P 〈0.05）.Conclusions Flurbiprofen axetil combined with Azasetron can reduce the adverse reactions, such as pain,nausea and vomiting in children undergoing strabismus surgery.

关 键 词：氟比洛芬酯 阿扎司琼 小儿斜视矫正术 镇痛 术后恶心呕吐 

分 类 号：R442.1[医药卫生—诊断学]