云克联合辛伐他汀治疗类风湿性关节炎骨质疏松疗效观察  

The efficacy observation of the treatment of rheumatoid arthritis using Yunke combined with simvastatin

作　　者：刘爱学[1] 王慧凤[2] 李中文[1] 赵嘉英[1] 杨兆文[1] 王小娟[3] 刘健[1] 

机构地区：[1]河北省秦皇岛市第一医院免疫科,秦皇岛066000 [2]河北省秦皇岛市第一医院护理部,秦皇岛066000 [3]河北省秦皇岛市第一医院综合科,秦皇岛066000

出　　处：《中国骨质疏松杂志》2011年第4期340-343,共4页Chinese Journal of Osteoporosis

基　　金：河北省秦皇岛市科技局2008年度科研指导项目

摘　　要：目的探讨辛伐他汀联合云克对类风湿关节炎(RA)患者骨密度(BMD)的变化和骨质疏松(OP)的影响。方法选择115例RA伴骨质疏松(OP)患者,随机分为治疗组(58例)和对照组(57例)2组。治疗组给予云克(锝99-亚甲基二磷酸盐)和辛伐他汀联合2种缓解疾病的抗风湿性药物(DMARD)。对照组给予2种常规DMARD药物治疗。治疗周期6月。比较两组患者治疗前、治疗后6个月血脂(TC、LDL-C)、碱性磷酸酶(ALP)、血钙、血磷、肝肾功能、C反应蛋白(CRP)、类风湿因子(RF)、血沉(ESR)等指标。测量患者治疗前后腰椎骨密度和非贯用桡骨骨密度(BMD)。结果云克联合辛伐他汀治疗组患者骨代谢指标ALP治疗前后有明显变化,腰椎和桡骨骨密度(BMD)增加,差异有统计学意义P<0.05。对照组患者治疗前后ALP无变化,BMD有下降。结论常规剂量的辛伐他汀联合云克治疗能增加RA患者BMD,改善患者的OP。Objective To explore the influence of combined use of Yunke and simvastatin for bone mineral density and osteoporosis in rheumatoid arthritis （RA） patients. Methods One hundred and fifteen patients with rheumatoid arthritis and osteoporosis were randomly divided into treatment group （58 cases） and control group （57 cases）. The patients in treatment group were administered with Yunke （Te-99）, simvastatin, and 2 anti-rheumatoid drugs. The patients in control group were administered with 2 common-used anti- rheumatoid drugs. The time course of the treatment was 6 months. Blood levels of TC, LDL, ALP, calcium, phosphate, CRP, RF, and ESR were determined before and after the treatment. Bone mineral density （BMD） in the lumbar spine and the non-dominant forearm bone were also examined before and after the treatment. Results The ALP level, a bone metabolic parameter, was significant altered in patients of Yunke combined with simvastatin treatment group before and after the treatment. BMDs in the lumbar spine and the radius were increased with statistic difference （P 〈 0.05 ）. ALP level was not changes in the patients of control group before and after the treatment. BMD was decreased in these patients. Conclusion Treatment with common dose of simvastatin combined with Yunke can increase BMD of RA patients, and ameliorate their osteoporosis.

关 键 词：辛伐他汀 云克 类风湿关节炎 骨密度 骨质疏松 

分 类 号：R544.2[医药卫生—心血管疾病]