钙剂、活性维生素D_3对十堰地区低骨量人群的干预  

Calcium and active vitamin D_3 intervention on osteopenia people in Shiyan region

作　　者：陈霞平[1] 王俊华[2] 王刚[2] 万超[2] 骆小娟[2] 尹晶[2] 朱小虎[2] 

机构地区：[1]湖北医药学院附属太和医院药物临床试验办公室,十堰442000 [2]湖北医药学院附属太和医院康复医学中心

出　　处：《中国骨质疏松杂志》2011年第4期347-349,共3页Chinese Journal of Osteoporosis

基　　金：全国不同地域不同民族周围骨骨密度测量暨骨质疏松的不同药物与不同治疗方案对低骨量人群疗效观察及机理探讨(民人教科字[2008]47-1-43)

摘　　要：目的应用钙剂、活性维生素D3对低骨量人群进行干预治疗,观察其对BMD、BGP、DPD及预防骨质疏松的作用。方法选取骨量减少患者100例,随机分成对照组和治疗组,每组50例,对照组服用乐力(2g/d),治疗组服用乐力(2g/d)和阿法迪三(0.5μg/d),连续治疗12个月。在治疗前、治疗后6月和12月检测BMD、BGP、DPD。结果两组经治疗后BMD、BGP均较治疗前增加(P<0.05),DPD下降(P<0.05),以治疗组差异更为明显,组间比较有统计学意义(P<0.05)。结论骨量减少应早期干预治疗,钙剂与活性维生素D联合应用可以更有效地预防及延缓骨质疏松的发生。Objective Using calcium and active vitamin D3 intervention treatment on osteopenia patients to observe their effect on BMD, BGP, and DPD, and on prevention and treatment of osteoporosis. Methods One hundred osteopenia patients were assigned randomly to control group and treatment group, 50 patients in each group. The patients in control group were administered calcium （2g/d）, and the patients in treatment group were administered calcium （2g/d） and active vitamin D3 （0. 5 g/d） for 12 months continuously. BMD, BGP, and DPD were measured before and after the treatment. Results BMD and BGP were increased in both groups after the treatment （P 〈 0. 05）, but DPD was decreased （P 〈 0.05）. The difference was more significant in treatment group, with statistical significance between the two groups （ P 〈 0.05）. Conclusion The osteopenia patients should be treated early. Combined use of calcium and active vitamin D3 could effectively prevent and postpone the occurrence of osteoporosis.

关 键 词：骨量减少 骨质疏松 骨密度 骨代谢指标 钙 阿法骨化醇 

分 类 号：R681[医药卫生—骨科学]