前列腺素E_1对心肺转流中全身炎性反应的抑制作用  

Inhibition effects of PGE_1 on SIRS during open heart surgery under cardiopulmonary bypass

作　　者：甄福喜[1] 陈亮[1] 朱全[1] 赵飞[1] 闻伟[1] 张石江[1] 

机构地区：[1]南京医科大学第一附属医院胸心外科,210029

出　　处：《江苏医药》2011年第9期1043-1045,共3页Jiangsu Medical Journal

摘　　要：目的探讨前列腺素E1（PGE1）对心肺转流（CPB）后全身炎性反应（SIRS）的抑制作用。方法 30例心脏手术患者随机分为对照组（15例）和实验组（15例,PGE1治疗组）。实验组于麻醉诱导时从中心静脉持续泵入PGE1（20~30 ng.kg-1.min-1）至CPB结束。分别于转流前、心脏复跳后15 min、CPB结束后2 h及6 h检测循环血中中性粒细胞（PMN）计数、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）及IL-8。结果两组心脏复跳后血PNM计数进行性升高,CPB结束后2 h达高峰。实验组CPB后2 h、6 h血PMN计数显著低于对照组（P〈0.01、P〈0.05）;两组TNF-α、IL-6、IL-8进行性升高,于心脏复跳后达到峰值,随后逐渐下降,至CPB后6 h仍高于CPB前;对照组较实验组增高则更为显著（P〈0.05）。结论 PGE1可抑制CPB引起的中性粒细胞的激活、减少炎性因子的释放并减轻由此引起的SIRS。Objective To study the protective effects of prostaglandin E1（PGE1） on systemic inflammatory response syndrome（SIRS） after cardiopulmonary bypass（CPB）.Methods Thirty patients undergoing cardiac surgery under CPB were randomly divided into two groups of control（group C） and PGE1 treatment（group P,PGE1 20-30 ng·kg-1·min-1 during operation） with 15 cases each.Neutrophil count（PNM）,tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）,IL-8 were detected before CPB,at 15 minutes after the heart resuscitation and at 2 and 6 hours after CPB.Results PNM was significantly less in group P than that in group C at 2 and 6 hours after CPB（P0.01,P0.05）.The levels of TNF-α,IL-6 and IL-8 in group P were also significantly lower than those in group C after CPB（P0.05）.Conclusion PGE1 can attenuate SIRS by effectively reducing the activation of neutrophil and the levels of TNF-α,IL-6 and IL-8 during CPB.

关 键 词：前列腺素E1 心肺转流 全身炎性反应综合征 

分 类 号：R453[医药卫生—治疗学]