间充质干细胞对免疫细胞的抑制作用及其机制  

Immunosuppressive Effect and Mechanism of Mesenchymal Stem Cells on Immunocytes

作　　者：王晓宇[1] 侯玲玲[1] 马海滨[1] 关伟军[2] 马月辉[2] 

机构地区：[1]北京交通大学生命科学与生物工程研究院,北京100044 [2]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《中国生物化学与分子生物学报》2011年第5期397-402,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家"十一五"科技支撑计划重点项目(No.2008BAK41B01-5);国家科技基础条件平台建设项目(No.2005DKA21101);转基因生物新品种培育科技重大专项(No.2008ZX08009-003)~~

摘　　要：间充质干细胞是一群来源于发育早期中胚层的具有自我更新和多向分化潜能的干细胞,具有分化为脂肪细胞、肝细胞、成骨细胞、软骨细胞、神经细胞等多种细胞的能力.近年来的相关研究表明,间充质干细胞具有低免疫原性,它可以通过抑制淋巴细胞的增殖、抑制抗原呈递细胞分化成熟及功能发挥、抑制细胞毒性T淋巴细胞的形成、增加调节性T细胞比例等多种途径发挥免疫调节作用,从而成为移植领域、各种退行性和衰竭性疑难病症的替代治疗的研究热点.本文就间充质干细胞对免疫细胞的抑制作用及其机制的研究进展进行综述.Mesenchymal stem cells（MSCs） are self-renewed and multipotential stem cells that are isolated from many adult tissues,including bone marrow,liver tissue,lung tissue,amnion tissue,adipose tissue and umbilical cord.It was proved that MSCs could differentiate into mesodermal and ectodermal cell types,such as adipocytes,liver cells,osteoblasts,chondrocytes and neural cells.In recent years,the relevant studies show that MSCs are low immunogenic.It plays an important role in immunoregulation by inhibiting the proliferation of lymphocytes,the differentiation,maturity and function of the antigen-presenting cell and the formation of（cytotoxic T lymphocyte,CTL）,as well as by increasing the proportion of the regulatory T cells.Based on the special immunological characteristics,MSCs study becomes a＂hot spot＂in the fields of transplantation and also the replacement therapy of many degenerative and prostrating diseases.This review summarized the inhibition effect and mechanism of MSCs on immunocytes.

关 键 词：间充质干细胞 免疫调节 机制 

分 类 号：Q813[生物学—生物工程]