缺氧和氰化钠中毒对犬心电信号及血清AST、ALT的影响  

Effects of hypoxia and sodium cyanide intoxication on electrocardiogram signals and AST,ALT in blood serum of dogs

作　　者：张晋煜[1,2] 蔡颖[1] 唐禾[1] 何悦[1] 董兆君[1] 

机构地区：[1]第三军医大学军事预防医学院防化医学教研室,重庆400038 [2]云南省肿瘤医院骨科,云南昆明650118

出　　处：《局解手术学杂志》2011年第3期263-265,共3页Journal of Regional Anatomy and Operative Surgery

基　　金：军队"十一五"医学科研基金攻关项目(06G077)

摘　　要：目的研究缺氧家犬氰化钠中毒后,外周血谷草转氨酶(AST)、谷丙转氨酶(ALT)及心脏电信号的变化规律。方法四川杂种家犬18只,分为常氧组和缺氧组,麻醉后行气管插管术、安放心电电极。常氧组吸入空气,缺氧组吸入81.8%?18.2%的氮-氧混合气体,1 h后皮下注射NaCN3.6 mg/kg。于中毒前即刻(0 min)和中毒后10 min、20 min、30 min、50 min取外周血测定AST和ALT。记录Ⅱ导联心电图,测量PP间期(PPd)、PQ间期(PQd)和QRS间期(QRSd)。结果单纯缺氧能显著影响外周血ALT及PQd,单纯氰中毒能影响AST、ALT和PPd、PQd;而缺氧与氰中毒两种因素同时存在时,上述指标均显著改变。结论缺氧和氰化钠中毒对狗心脏功能有联合效应。Objective To study the effects of acute hypoxia and sodium cyanide（NaCN） intoxication on electrocardiogram signals and AST,ALT in blood serum of dogs.Methods Eighteen dogs were randomly divided into normoxic and hypoxic groups.Endotracheal intubation was taken after anesthesia and ECG electrodes were placed.The dogs in normoxic group breathed the air while those in hypoxia group inhaled nitrogen-oxygen mixture in proportion as 81.8% ： 18.2%.NaCN in a dose of 3.6 mg/kg was injected subcutaneously to dogs in hypoxia group one hour after the operation.Glutamic-oxalacetic transaminease（AST）,glutamic-pyruvic transaminase（ALT） and electrocardiogram signals of PPd,PQd and QRSd were recorded and analyzed respectively at 0,10,20,30 and 50 min after intoxication.Results Acute hypoxia can significantly affect ALT and PQd while sodium cyanide can change AST、ALT,PPd and PQd,However,all of the changes were enhanced by the combination of hypoxia and sodium cyanide intoxication.Conclusion Acute hypoxia and sodium cyanide intoxication could produce combined effects on cadiac function in dogs.

关 键 词：缺氧 氰化钠 心脏 犬 

分 类 号：R594.3[医药卫生—内科学] R827.17[医药卫生—临床医学]