巯基与铜、汞、铅和三价砷反应初步研究  

Preliminary Study on Reactions of Sulfhydryl Group with Cu 2+ ,Hg 2+ ,Pb 2+ and Arsenides

作　　者：王连方[1] 刘惠君[1] 艾山江.艾比布 

机构地区：[1]新疆地方病防治研究所

出　　处：《地方病通报》1999年第3期1-3,共3页Endemic Diseases Bulletin

基　　金：国家自然科学基金;卫生部科学研究基金

摘　　要：为了查明活性巯基与常见毒性元素结合能力，为临床应用巯基化合物进行解毒提供依据，在实验室中应用直接结合方法研究了巯基与Ｃｕ２＋，Ｈｇ２＋，Ｐｂ２＋和砷化物的反应，发现半胱氨酸巯基３μｇ与（１～５）μｇＣｕ２＋，Ｈｇ２＋成线性反应，相关系数分别大于０．９９０（Ｐ＜０．００１），半胱氨酸或二巯基丙醇巯基与Ｐｂ２＋，Ａｓ２Ｏ３，ＮａＡｓＯ２无明显结合。作者认为半胱氨酸有可能用作铜或汞中毒的解毒剂，巯基仅在砷转变为某种如三价带苯环结构形式才能反应。The reactions of sulfhydryl group with Cu 2+ ,Hg 2+ Pb 2+ and arsenides were studied at laboratory.The results showed that the reaction of sulfhydryl group(3 μg) of cysteine with Pb 2+ ,As 2O 3 and NaAsO 2, and the reactionsto a series of (1～5) μg of Cu 2+ and Hg 2+ were linear with correlation coefficient over 0.990(P<0.001),respectively, the authors considered that cysteine may be used as antidote for copper or mercury poisoning and that the thiol group react to arsenic only when tyey turn into some forms such as trivalent arsenide with benzol ring formation,.

关 键 词：巯基 铜 汞 三价砷 反应 解毒药 金属中毒 

分 类 号：R595.205[医药卫生—内科学] R979.3[医药卫生—临床医学]