景洪哥纳香中苯乙烯内酯的UPLC-Q-TOF-MS分析  

Analysis of styryllactones from Goniothalamus cheliensis by UPLC-Q-TOF-MS

作　　者：姜苗苗[1] 芮雯[1] 符方方[1] 赵丽丽[1] 姚新生[2] 冯毅凡[1] 

机构地区：[1]广东药学院中心实验室,广东广州510006 [2]暨南大学中药及天然药物研究中心,广东广州510632

出　　处：《中国中药杂志》2011年第10期1322-1326,共5页China Journal of Chinese Materia Medica

摘　　要：目的:采用超高效液相色谱与串联四级杆飞行时间质谱联用技术(UPLC-Q-TOF-MS)建立快速鉴景洪哥纳香中苯乙烯内酯类化合物的方法。方法:应用ACQU ITY UPLC BEHC18色谱柱,以0.1%甲酸水溶液(A)-乙腈(B)为流动相梯度洗脱,检测波长254 nm,电喷雾离子源,正离子模式下采集数据。结果:根据质谱信息推测了该植物氯仿提取物中12个苯乙烯内酯的结构。结论:本方法分离度好、灵敏度高、快速高效地鉴定了植物中的苯乙烯内酯,同时本文探讨了苯乙烯内酯类化合物的质谱裂解规律。Objective： To analyze the styryllactone components in Goniothalamus cheliensis Hu（Annonaceae）.Method： UPLC-Q-TOF-MS was used to identify the main styryllactone components in G.cheliensis.The chromatographic separation was performed on ACQU ITY UPLC BEH C18 column and eluted by actonitrile and 0.1% acetic acid in water gradiently.The mass spectrometer equipped with electrospray ionization souce was used as detector under the positive ion modes.Result： Twelve styryllactons were identified based on their MS data and published literatures,and the MS fragmentation regularity of the styryllactones was also proposed.Conclusion： It is an accurate and effective method to obtain the structural information of styryllactones.

关 键 词：景洪哥纳香 苯乙烯内酯 UPLC—Q—TOF-MS 

分 类 号：R284.1[医药卫生—中药学]