人类鼻病毒感染与哮喘研究进展  

Progress of human rhinovirus infection and asthma

作　　者：王美怡(综述)[1] 张建华(审校)[1] 

机构地区：[1]上海交通大学附属第六人民医院儿科,200233

出　　处：《国际儿科学杂志》2011年第3期232-235,共4页International Journal of Pediatrics

摘　　要：人类鼻病毒（HRV）是引起呼吸道感染的常见病原体,研究显示HRV感染不仅是引起哮喘急性发作的常见诱因,而且对婴幼儿的早期感染在儿童哮喘形成过程中也起着重要作用.HRV主要通过感染呼吸道上皮细胞、促使炎症介质释放、引起免疫反应及造成气道重塑等机制引起哮喘相关症状.进一步了解HRV感染对哮喘的影响及相关机制,可为降低哮喘发病率及减少哮喘急性发作提供有效的预防和治疗.Human rhinovirus （HRV） is a common pathogen causing respiratory tract infection, and recent studies have shown that HRV infection is not only a cause of asthma acute exacerbation, but their early infection in infants and young children also plays an important role during the formation of asthma in children. HRV causes asthma relevant symptoms mainly by the following mechanisms, infection of bronchial epithelial cells, to promote the release of inflammatory mediators, the immune response and to cause airway remodeling. Learning more about the impact of HRV infection on asthma and related mechanisms will help us to find effective prevention and treatment methods to reduce asthma morbidity and acute exccrbation.

关 键 词：人类鼻病毒 哮喘 急性发作 

分 类 号：R725.622.5[医药卫生—儿科]