积雪草提取物对胃粘膜的保护作用及其机制探讨  

Protection of titracted extract of centella asiatica on gastric mucosa and its possible mechanism

作　　者：陈宝雯[1] 纪宝安[1] 张学智[1] 谢竹藩[1] 贾博琦[1] 

机构地区：[1]北京医科大学第一医院

出　　处：《中华消化杂志》1999年第4期246-248,共3页Chinese Journal of Digestion

基　　金：国家自然科学基金

摘　　要：目的观察积雪草提取物（ＴＣＡ）对胃粘膜损伤的防治作用及其可能的机制。方法采用大鼠胃损伤模型，测定损伤指数、髓过氧化物酶（ＭＰＯ）、丙二醛（ＭＤＡ）、细胞因子、胃粘膜细胞存活率等。结果（１）ＴＣＡ对乙醇胃粘膜损伤具有预防作用；（２）对乙酸胃溃疡具有治疗作用；（３）可以降低ＭＰＯ、ＭＤＡ、ＩＬ８的产生；（４）可以增加胃粘膜细胞的存活率。结论（１）ＴＣＡ对胃粘膜损伤有防治作用；（２）ＴＣＡ降低血管的通透性及减少ＭＰＯ、ＭＤＡ、ＩＬ８；（３）对胃粘膜细胞的直接保护作用可能是其作用机制之一。Objective To study the gastric mucosal protective effect of titracted extract of centella asiatica (TCA) and its possible mechanism in rats. Methods To adopt gastric damage models in rats; detect damage index; myloperoxidase (MPO); malonaldehyde (MDA); cytokines; gastric mucosal cell viability etc. Results (1)TCA could prevent gastric mucosal damage from ethanol; (2) TCA could exert therapeutic effect on gastric ulcer induced by acetic acid; (3) MPO, MDA, IL8 were all decreased and gastric mucosal cell viability increased. Conclusion (1)TCA has preventive and therapeutic effects on gastric mucosal injury; (2) TCA reduces vascular permeability MPO, MDA and IL8; (3)TCA has direct protective effect on gastric mucosal cell, one of its mechanism may be cytoprotection.

关 键 词：积雪草提取物 胃粘膜保护 细胞因子 药理 

分 类 号：R975[医药卫生—药品] R931.71[医药卫生—药学]