某医院2007年至2009年医院感染不动杆菌属耐药调查分析  

Antibiotic-resistance of Acinetobacter spp nosocomial infection:analysis from 2007 to 2009

作　　者：曲文秀[1] 张智杰[2] 颜恒毅[1] 赵立[1] 

机构地区：[1]中国医科大学附属盛京医院第一呼吸科,辽宁沈阳110004 [2]中国医科大学附属盛京医院检验科,辽宁沈阳110004

出　　处：《中国微生态学杂志》2011年第5期450-452,455,共4页Chinese Journal of Microecology

摘　　要：目的了解医院感染不动杆菌属细菌对临床常用抗菌药物耐药现状。方法对2007年至2009年852例不动杆菌属医院感染病例进行回顾性调查及耐药情况统计。结果不动杆菌属主要来源于痰液(60%)和血液(8%)标本,3年间17种抗生素耐药水平差异均有统计学意义;852株不动杆菌属对17种抗菌药物总耐药率:头孢哌酮/舒巴坦35.13%、亚胺培南/西司他丁46.4%、美罗培南51.0%、阿米卡星64.7%、四环素66.7%、左氧氟沙星67.1%、替卡西林/克拉维酸67.8%、环丙沙星68.0%、头孢吡肟68.7%、哌拉西林/他唑巴坦70.1%、头孢他啶70.5%、头孢曲松71.6%、头孢噻肟72.8%、庆大霉素73.5%、哌拉西林73.8%、复方新诺明77.3%和头孢哌酮86.8%。结论不动杆菌属细菌对临床常用抗菌药物耐药现象严重,仅头孢哌酮/舒巴坦、亚胺培南/西司他丁、美罗培南保持相对高的抗菌活性。Objective To investigate the drug-resistance rate of strains isolated from patients with nosocomial infection of Acinetobacter spp.Method A total of 852 patients with Acinetobacter spp nosocomial infection from 2007 to 2009 were studied retrospectively.The antibiotic resistance profiles were specifically analyzed.Result The strains of Acinetobacter spp were mainly isolated from sputum（60%） and blood（8%） specimens.There were significant differences in the resistance of Acinetobacter spp against antibiotics in the 3 years.The resistance rates of all 852 strains to 17 kinds of antibiotics were as following： cefoperazone/sulbactam 35.1%,imipenem/cilastatin 46.4%,meropenem 51.0%,amikacin 64.7%,tetracycline 66.7%,levofloxacin 67.1%,ticarcillin/clavulanic acid 67.8%,ciprofloxacin 68.0%,cefepime 68.7%,piperacillin/tazobactam 70.1%,ceftazidime 70.5%,ceftriaxone 71.6%,cefotaxime72.8%,gentamicin 73.5%,piperacillin 73.8%,sulfamethoxazole/trimethoprim 77.3%,and cefoperazone 86.8%.Conclusion Acinetobacter spp are highly resistant to common antibiotics,but sensitive to cefoperazone/sulbactam imipenem/cilastatin and meropenem.

关 键 词：医院感染 不动杆菌属 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]