邻苯二胺与醛反应合成苯并咪唑衍生物的反应机理研究  

Investigation on the Reaction Mechanism for the Synthesis of Benzimidazole Derivatives from Aldehydes and o-Phenylenediamine

作　　者：崔丽君[1] 肖尚友[1] 杨昊书[1] 徐盼[1] 程凡圣[1] 李正华[1] 梁荣辉[1] 夏之宁[1] 

机构地区：[1]重庆大学化学化工学院,重庆400030

出　　处：《有机化学》2011年第5期672-676,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20775096);国家重点基础研究发展计划(973;Nos.2009CB724501;2009CB724502);科技部国际合作(No.2010DFA32680)资助项目

摘　　要：以4-甲基苯甲醛与邻苯二胺反应合成2-(4-甲基苯基)苯并咪唑的反应为例,以HPLC方法跟踪反应进程,对关键中间体与产物的结构通过1H NMR,FT-IR及LC-MS等手段进行了表征.实验证明了在邻苯二胺和醛物质的量比为1∶1时同时生成单席夫碱和双席夫碱中间体的反应机理,并提出了该类反应的影响规律.The synthesis of 2-（4-methyphenyl）benzimidazole from 4-methyl benzylaldehyde and o-phenylenediamine was performed.The reaction process was monitored by HPLC,and the structures of re-lated intermediates and products were identified by 1H NMR,FT-IR and LC-MS techniques.The experi-ments proved that mono-Schiff base and bis-Schiff base could both be synthesized at the same time when o-phenylenediamine and aldehydes were in a molar ratio of 1∶1,and the influences of the reaction were pro-posed.

关 键 词：芳香醛 邻苯二胺 苯并咪唑衍生物 反应机理 

分 类 号：O626.23[理学—有机化学]