基于MCM-41微反应器的微波辅助合成新方法研究  

Investigation on Novel Microwave-Assisted Synthesis Method Based on MCM-41 Microreactor

作　　者：肖尚友[1] 杨昊书[1] 李倩倩[1] 邱静[1] 夏之宁[1] 

机构地区：[1]重庆大学化学化工学院,重庆400030

出　　处：《有机化学》2011年第5期690-694,共5页Chinese Journal of Organic Chemistry

基　　金：科技部国际合作计划(No.2006DFA43520);中央高校基本科研业务费(No.CDJXS10220010)资助项目

摘　　要：采用微波辐射合成法合成了纳米介孔分子筛MCM-41作为微反应器.以苯并呋喃-2(3H)-酮的合成为实例,在甲苯介质中将邻羟基苯乙酸组装到MCM-41微反应器中,研究了溶液体系及微反应器中反应温度、反应时间及微波辐射时间对反应的影响.结果显示,在施加微波与不施加微波情况下,MCM-41微反应器中进行的反应较溶液体系中进行的反应产率提高了2～33与2～12倍.对于MCM-41微反应器中的反应,施加微波辐射后反应产率可进一步提高20%～100%.MCM-41 mesoporous molecular sieve was synthesized under microwave irradiation and used as microreactor.2-Hydroxyphenylacetic acid was assembled into MCM-41 microreactor in toluene solution,and benzofuran-2（3H）-one was obtained by the intramolecular esterification of 2-hydroxyphenylacetic acid with high selectivity.The reaction conditions including temperature,reaction time,microwave irradiation and so on were investigated.The yield of benzofuran-2（3H）-one was improved by 2～12 and 2～33 times in MCM-41 microreactor than that in solution under conventional heating and microwave irradiation respec-tively.In addition,the yield of the reaction in MCM-41 reactor under microwave irradiation could be im-proved by 20%～100%.

关 键 词：MCM-41 微反应器 邻羟基苯乙酸 苯并呋喃-2(3H)-酮 

分 类 号：O621.3[理学—有机化学]