新型含三唑及噻唑环的腙类化合物的合成及生物活性研究  

Synthesis and Biological Activity of Some Novel Hydrazones Containing Triazole and Thiazole

作　　者：阿布拉江.克依木 

机构地区：[1]新疆大学化学化工学院,乌鲁木齐830046

出　　处：《有机化学》2011年第5期724-727,共4页Chinese Journal of Organic Chemistry

基　　金：新疆维吾尔自治区自然科学基金(No.2009211A02)资助项目

摘　　要：为寻找具有医用或农用生物活性的新颖化合物,以对氯苯胺为起始原料,经由四步反应,制得1-对氯苯基-5-甲基-1,2,3-三唑-4-乙酮缩氨基硫脲(3),随后中间体3与ω-溴代芳基乙酮在无水乙醇中回流或在超声波辐射下反应,得到了一系列新型N-(1-对氯苯基-5-甲基-1,2,3-三唑-4-乙酰基)-N′-(4-芳基-噻唑-2-基)腙类化合物.用1H NMR,MS谱和元素分析对所有化合物进行了结构表征.初步生物活性测试表明,化合物4d和4e表现出一定的生物活性.In order to find novel compounds with medical or agricultural bioactivity,1-chlorophenyl-5-methyl-1,2,3-triazol-4-ethanonethiosemicarbazone was obtained from p-chlorophenylamine as starting materials by four-step reaction,followed by the reaction of intermediate 3 with ω-bromoacetophenone under reflux con-dition or ultrasonic irradiation to afford a series of N-（1-p-chlorophenyl-5-methyl-1,2,3-triazole-4-acetyl）-N＇-（4-aryl-thiazol-2-yl）-hydrazones.The structures of all compounds were characterized by elemental analy-sis,1H NMR and MS techniques.The results of preliminary bioactivity tests indicated that compounds 4d and 4e possess certain biological activities.

关 键 词：1 2 3-三唑 噻唑 腙 合成 生物活性 

分 类 号：O626[理学—有机化学]