混合三烃基卤化锡二苯基环己基碘化锡和甲基二环己基氯化锡与巯基乙酸在有机胺存在下的反应产物及生物活性研究  

Reaction of Ph_2CySnI and MeCy_2SnCl with HSCH_2COOH in the Presence of Organic Amines and Biological Activity for the Reaction Products

作　　者：钟桂云[1] 刘清福[1] 孙丽娟[2] 谢庆兰[2] 

机构地区：[1]江门职业技术学院材料技术系,江门529090 [2]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2011年第5期728-732,共5页Chinese Journal of Organic Chemistry

摘　　要：在有机胺的存在下,Ph2CySnI和MeCy2SnCl与HSCH2COOH反应,得到了非锡碳键断裂的五配位阴离子型有机锡化合物和锡碳键断裂的有机锡聚合物两类产物.对于有机胺作为缚酸剂,有机锡卤化物与有机酸反应机理的研究进行了深入探讨.通过IR,1H NMR,13C NMR,元素分析对反应产物进行了表征,确定了反应产物的结构.测定了反应产物体外对人类肺癌肿瘤细胞(A-549)、结肠癌肿瘤细胞(HCT-8)和肝癌肿瘤细胞(Bel-7402)的抑制活性,结果表明该类化合物具有很强的体外抗肿瘤活性.The reaction of Ph2CySnI and MeCy2SnCl with HSCH2COOH in the presence of organic amine was studied.Two type of products were generated in this reaction.One was no Sn—C cleavage anionic organic tin compound and another was Sn—C cleavage organic tin polymer product.The products have been character-ized by elemental analyses,IR,1H NMR and 13C NMR spectroscopies.The structures of the products were de-termined.The activity of the products showed that these compounds have a strong anti-tumor activity in vitro.

关 键 词：五配位有机锡化合物 离子型有机锡 有机锡聚合物 

分 类 号：O621.25[理学—有机化学]