碱性离子液体催化下一锅三组分合成螺环吲哚衍生物  

One-Pot Three-Component Synthesis of Spirooxindoles Catalyzed by Basic Ionic Liquids

作　　者：郭红云[1] 田金金[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310014

出　　处：《有机化学》2011年第5期752-756,共5页Chinese Journal of Organic Chemistry

摘　　要：在碱性离子液体[H3N+CH2CH2OH][CH3COO-]催化作用下,由靛红、丙二腈/氰乙酸乙酯和β-二酮三组分"一锅法"合成了一系列螺环吲哚类化合物,产物的结构通过1H NMR,IR和MS表征.该方法条件温和,操作简单,后处理方便,反应时间短,对环境友好,且催化剂廉价易得.A series of spirooxindoles were synthesized by a three component,one pot condensation of isatin,malononitrile/ethyl cyanoacetate and β-diketone using [H3N＋CH2CH2OH][CH3COO-] as a basic ionic liquid catalyst.The products were identified by 1H NMR,IR and MS techniques.This method has some distinct advantages such as mild reaction conditions,short reaction time,environmental friendliness and accessibility of catalyst.

关 键 词：碱性离子液体 一锅 三组分 螺环吲哚 

分 类 号：TQ252[化学工程—有机化工]