美能联合液氮冷冻治疗白癜风疗效观察  

Observation on the efficacy of compound glycyrrhizin tablets combined with liquid nitrogen cryotherapy in treatment of viltiligo

作　　者：张霞[1] 李丹[2] 阮征[1] 阮建波[1] 朱瑞青[1] 林振仁[1] 王雅文[1] 

机构地区：[1]东莞市太平人民医院皮肤科,广东东莞523900 [2]东莞市人民医院皮肤科,广东东莞523000

出　　处：《中国热带医学》2011年第5期626-628,共3页China Tropical Medicine

摘　　要：目的探讨美能联合液氮冷冻治疗白癜风的疗效和安全性。方法 60例白癜风患者随机分成两组。对照组30例,口服美能片50mg3次/d,外用卤米松软膏1次/d,每连续外用2周停1周,疗程16周。治疗组30例,液氮冷冻治疗1次/周,余药用法同对照组。结果治疗组有效率为76.67%,对照组为43.33%,两组有效率差异有统计学意义(P<0.05)。治疗组皮损位于面颈部、躯干和四肢者疗效优于对照组(P<0.05),两组肢端皮损疗效差异无统计学意义(P>0.05)。两组患者均未出现严重不良反应。结论美能联合液氮冷冻治疗位于面颈部、躯干和四肢的白癜风疗效好,不良反应少。Aim To investigate the efficacy and safety of compound glycyrrhizin tablets combined with liquid nitrogen cryotherapy in the treatment of vitiligo.Methods Sixty patients with vitiligo were divided into two groups randomly.Thirty patients of control group were treated with compound glycyrrhizin 50mg three times a day and halometasone cream once a day for 16 weeks.Thirty patients of treatment group were treated as that of the control group plus liquid nitrogen cryotherapy once weekly for 16 weeks.Results The total effective rates in the treatment group and the control group were 76.67% and 43.33%,showing signficant difference between the two groups（P0.05）.The effect of treatment group is superior to that of control group to the vitiligous lesions located on face neck trunk and extremities（P0.05）.However,there was not statistical significant difference between two groups in the effective rate of acral lesions（P0.05）.No serious adverse events were recorded in both groups.Conclusion The combination of compound glycyrrhizin with liquid nitrogen cryotherapy can represent an effective and well-tolerated approach to vitiligo located on face,neck trunk and extremities.

关 键 词：美能 液氮冷冻 白癜风 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]