胸科手术术后认知功能障碍的危险因素分析  

Risk factors contributing to postoperative cognitive dysfunction in patients undergoing thoracic surgery

作　　者：彭志友[1] 封小美[1] 薛庆生[1] 于布为[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院麻醉科,200025

出　　处：《临床麻醉学杂志》2011年第5期433-435,共3页Journal of Clinical Anesthesiology

基　　金：国家自然科学基金(30901409)

摘　　要：目的分析行单肺通气的胸科手术患者发生术后认知功能障碍(POCD)的危险因素。方法 46例需单肺通气的胸科手术患者于术前1 d和术后7 d分别行神经心理测验,以此评价手术前后认知功能的改变,并分析围术期因素和患者发生POCD的关系。结果共有12例患者发生POCD。单肺通气后乳酸升高和脑氧饱和度下降与患者POCD的发生呈正相关。结论单肺通气后乳酸升高和脑氧饱和度下降是行单肺通气的胸科手术患者发生POCD的危险因素。Objective To analyze the risk factors asociated with postoperative cognitive dysfunction （POCD） in the patients undergoing thoracic surgery. Methods Neuropsychological tests was performed in forty six patients 1 day before operation and on the 7th postoperative day to evaluate the changes of cognitive function The relations between perioperative risk factors and POCD were analyzed. Results POCD was present in 12 of the 46 patients at one week after surgery. Accumulation of lactate after one hlng ventilation and the drop of cerebral oxygen saturation were the significant risk factors for POCD. Conclusion The accumulation of lactate after one lung ventilation and the drop of cerebral oxygen saturation are the risk factors for POCD in patients undergoing thoracic surgery.

关 键 词：单肺通气 术后认知功能障碍 

分 类 号：R614[医药卫生—麻醉学]