脂联素及高敏C反应蛋白与原发性高血压合并痛风的关系  

The relationship between adiponectin,high sensitivity C-reactive protein and essential hypertention plus gout

作　　者：莫新玲[1] 王要鑫[1] 谢福生[1] 李全忠[1] 

机构地区：[1]桂林医学院附属医院心内科,541001

出　　处：《实用医学杂志》2011年第10期1767-1769,共3页The Journal of Practical Medicine

基　　金：桂林市科学技术与应用开发项目(编号:20100128-7)

摘　　要：目的:探讨高血压合并痛风患者治疗前后血清脂联素(APN)、高敏C反应蛋白(hs-CRP)水平的变化并分析其之间的关系。方法:选择桂林医学院附属医院心内科门诊和住院患者120例,分为高血压合并痛风组60例、高血压组30例、痛风组30例3组。对照组30例为同期我院体检中心健康体检者。采用酶联免疫吸附法(ELISA)测定血清APN,免疫散射比浊法测定血清hs-CRP。结果:高血压合并痛风患者治疗后较治疗前APN升高,hs-CRP降低;高血压合并痛风组APN与hs-CRP呈负相关。结论:高血压合并痛风患者随血压及尿酸水平较低,血清APN升高,炎症标志物hs-CRP降低。Objective To investigate the changes of adiponectin（APN）and high sensitivity C-reactive protein（hs-CRP）in the treatment of essential hypertensive patients with gout,and to analyse the relationships between them.Methods The study enrolled 120 patients who visited the Affiliated Hospital of Guilin Medical College.These patients were divided into three groups：60 cases in essential hypertension with gout group;30 cases in essential hypertension group;30 cases in gout group.And other 30 cases of healthy individuals served as control group.Serum APN was evaluated using enzyme-linked immunosorbent assay（ELISA）,and plasma level of hs-CRP was assessed with immunoturbidimetry.Results The level of APN was significantly higher while the level of hs-CRP was significantly lower in patients of essential hypertension with gout after treatment;Negative correlations were found between APN and hs-CRP in essential hypertensive patients with gout group.Conclusion The level of APN decreased while hs-CRP increased as the blood pressure and uric acid decreased in the hypertensive patients with gout.

关 键 词：高血压 痛风 高敏C反应蛋白 脂联素 

分 类 号：R446.6[医药卫生—诊断学] R544.1[医药卫生—临床医学] R589.7