广西壮族IgA肾病与TCRC-α560C/T多态性的相关性研究  

Association of IgA Nephropathy of Zhuang Nationality with TCRCα-560C/T Polymorphism

作　　者：贺涤非[1] 廖蕴华[1] 薛超[1] 叶旭东[1] 卜昆鹏[1] 

机构地区：[1]广西医科大学第一附属医院肾内科,南宁市530021

出　　处：《广西医学》2011年第5期530-532,共3页Guangxi Medical Journal

基　　金：广西科学基金资助项目(06040097)

摘　　要：目的探讨T细胞受体保守域A lpha链基因(TCRα)-560C/T多态性与广西壮族人群IgA肾病的关系。方法广西壮族IgA肾病患者(IgA肾病组)115例,广西壮族健康人(健康对照组)131例,采用PCR-RFLP法和PCR产物直接测序法对TCR-560C/T基因的单碱基突变多态性进行分析。结果 IgA肾病组中TCR-560C/T基因多态CT、CC、TT基因型频率分别为46.96%、23.48%和29.56%,其中C和T等位基因频率分别为46.96%和53.04%。健康对照组中,TCR-560C/T基因多态CT、CC、TT基因型频率分别为47.33%、25.19%和27.48%,其中C和T等位基因频率分别为48.85%和51.15%。IgA肾病患者组与健康对照组比较,基因型频率差异无统计学意义(P>0.05),等位基因频率之间差异无统计学意义(P>0.05)。结论 TCT-560C/T等位基因可能不是广西壮族IgA肾病的易感基因。Objective To study on the relationship between TCR-560C/T and polymorphism with susceptibility of IgA nephropathy of Zhuang nationality in Guangxi.Methods 115 cases with IgA nephropathy and 131 healthy controls of Guangxi Zhuang nationality were recruited.Genotypes of TCR-560C/T were analyzed by PCR-RFLP in 115 patients with IgA nephropathy and 131 controls.Results The frequencies of T TCR-560C/T gene genotypes CT,CC,TT in patients with IgA nephropathy were 46.96%,23.48%,29.56%,respectively.The frequencies of alleles C and T were 46.96% and 53.04%,respectively.The frequencies of TCR-560C/T gene genotypes CT,CC,TT were 47.33%,25.19%,27.48% in control group,respectively.The frequencies of alleles C and T were 48.85% and 51.15%,respectively.The frequencies of TCR-560C/T genes genotypes in patients with IgA nephropathy were not significantly different from those in the controls（P0.05）.The frequencies of alleles C and T were not significantly different（P0.05）from those in the controls.Conclusion TCR-560C/T polymorphism may not association with IgA nephropathy of Zhuang nationality in Guangxi.

关 键 词：IGA肾病 T细胞受体 基因多态性 广西 壮族 

分 类 号：R692.31[医药卫生—泌尿科学]