用微电子神经桥实现受控脊蟾蜍运动功能重建的研究  

Experimental research on rebuilding the motive functions of a controlled spinal toad using the MENB method

作　　者：沈晓燕[1,3] 王志功[1] 吕晓迎[2] 黄宗浩[1] 李文渊[1] 赵鑫泰[1] 潘海仙[2] 方涛[2] 

机构地区：[1]东南大学射频与光电集成电路研究所,南京210096 [2]东南大学生物电子学国家重点实验室,南京210096 [3]南通大学电子信息学院,南通226019

出　　处：《高技术通讯》2011年第5期530-534,共5页Chinese High Technology Letters

基　　金：国家自然科学摹全（90307013,90707005）,江苏省自然科学基金（BK2008032）,生物电子学国家重点实验室开放基金和南通市自然科学基金（K2009037）资助项目.

摘　　要：在前期电刺激、机械刺激和化学刺激验证了采用微电子神经桥（MENB）实现神经功能重建的基础上，为了使受控脊蟾蜍重建的动作更加协调，以自由活动的蟾蜍的坐骨神经信号作为信号源，以脊蟾蜍的坐骨神经为受控对象，借助MENB实现了受控脊蟾蜍坐骨神经的功能重建。实验结果表明，受控脊蟾蜍在自由活动蟾蜍坐骨神经信号的控制下可以实现同步的伸缩腿动作。与其它刺激方式相比，这种刺激在动作协调性方面有了明显的改善。该研究工作提供了医疗康复训练的新途径。Based on the earlier stage result of the study that the realization of rebuilding biological neural functions using the microelectronic neural bridge （MENB） method was proved by using electrical, mechanical, and chemical stimulations, the sciatic nerve signal of a freely-moving toad was used as a signal source and the sciatic nerve was used as a controlled object in order to obtain an improved coordinative motion of the controlled spinal toad. In this way, once again the rebuilt neural functions of the toad was achieved in experiments, in which their sciatic nerves were connected by the MENB. The results show that the controlled spinal toad leg stretched synchronously with the freely-moving toad offering the source signal, and the coordinative motion of the toad was improved. This research and the results also show the application prospective of the MENB method for rehabilitation training of human being.

关 键 词：微电子神经桥(MENB) 神经功能重建 脊蟾蜍 康复训练 

分 类 号：TN41[电子电信—微电子学与固体电子学]