黄芪注射液对不稳定型心绞痛hs-CRP、TNF-α及sFas的影响  

THE CLINICAL INVESTEGATION OF ASTRAGALUS INJECTION ON UNSTABLE ANGINA PECTORIS AND THE EFFECTION OF PLASMA hs-CRP、TNF-α AND sFas

作　　者：刘卫民[1] 徐杰[1] 林丽[1] 王国振[1] 楚思鹏[2] 

机构地区：[1]滨州医学院实践教学医院阳信县人民医院内一科,山东省阳信县251800 [2]滨州医学院实践教学医院阳信县人民医院儿科,山东省阳信县251800

出　　处：《中国煤炭工业医学杂志》2011年第5期631-633,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的观察黄芪注射液对不稳定型心绞痛(UAP)患者的临床疗效及对血浆高敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)以及可溶性细胞凋亡因子Fas(sFas)的影响。方法将381例UAP患者按照数字表法随机分为A、B、C三组。所有患者均给予抑制血小板聚集、抗心绞痛等常规治疗。同时,B组患者加用黄芪注射液30～50ml,而C组患者加用黄芪注射液60～80ml入液静滴,1次/d,10d为1个疗程,应用1～2个疗程。观察三组患者的临床疗效以及治疗前后血浆hs-CRP、TNF-α及sFas水平的变化。结果黄芪注射液可以明显提高UAP患者的临床疗效,降低血浆hs-CRP、TNF-α和sFas水平,差异具有统计学意义(P<0.05或P<0.01),且以大剂量者为优。结论黄芪注射液治疗UAP疗效满意,能够抑制炎症反应和细胞凋亡,且以大剂量为优。Objective To investigate the efficacy of astragallus injection on unstable angina pectoris（UAP） and the effect of plasma high-sensitive C-reactive protein（hs-CRP）、tumor necrosis factor alpha（TNF-α）and soluble cell apoptosis factor Fas（sFas） in patients with UAP.Methods 381 patients with UAP who received the conventional therapies,such as antiplatelet and antianginal therapies were randomized into three groups,and 131 patients in the B group were given astragalus injection 30-50ml,while 144 patients in the C group were given astragalus injection 60-80ml,＋ 5% GS 250ml iv drip,qd,for 10 to 20 days.Results Astragalus injection could evidently improve the clinical treating efficacy of UAP、decrease levels of plasma hs-CRP、TNF-α and sFas.And they were better in high dose group（P0.05 or P 0.01）.Conclosion The efficacy of astragalus injection on UAP is satisfactory.Its mechanism may be related to improvement of inflammation response and cell apoptosis,and it＇s better in the high d astragallus injection group.

关 键 词：不稳定型心绞痛 黄芪注射液 高敏C反应蛋白 肿瘤坏死因子 可溶性细胞凋亡因子Fas 

分 类 号：R541.4[医药卫生—心血管疾病]