线粒体DNA定量分析与衰老关系初探  

Quantitative analysis of mitochondrial DNA associated with aging

作　　者：吴小晶 吴丽娟[2] 李晓东[2] 高枫[2] 

机构地区：[1]解放军第466医院内科,北京100089 [2]北京医科大学第一医院神经内科

出　　处：《中国老年学杂志》1999年第5期315-316,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助

摘　　要：目的　探讨线粒体 Ｄ Ｎ Ａ （ｍ ｔ Ｄ Ｎ Ａ ）相对含量与衰老的关系。方法　采用定量 Ｓｏｕｔｈｅｒｎ 杂交方法测定 ｍ ｔ Ｄ Ｎ Ａ 的相对含量。结果　大鼠大脑组织中老年组 ｍ ｔ Ｄ Ｎ Ａ 的相对含量明显高于其他组（ Ｐ＜ ００１），而幼年与成年组相比无明显差异（ Ｐ ＞００５）。结论　老年组大鼠大脑组织中 ｍ ｔ Ｄ Ｎ Ａ 的含量是增多的，而这种与年龄相关 ｍ ｔ Ｄ Ｎ Ａ 含量的变化可能始于成年以后。Effect of administration pathway and time vaviation of nimodipine on the neuromonoamine transmitter changes in hippocampal gyrus during cerebral ischemia injury$$$$ Zhu Xiaobo, Liu Baohuan, Wang Xiaoming et al The First Clinical Hospital of Norman Bethune University of Medical Science, Changchun 130021 In the experiment, the level of serum neuromonoamine transmitter in hippocampal gyrus in cerebral ischemiareperfusion using nimodipine by local therapy and general therapy in different time were measured. The results showed that treatment effect of early using nimodipine in reperfusion was better than that of the late, treatment effect of using nimodipine by local therapy was better than that of general therapy. Key words Cerebral ischemia reperfusion Nimodipine Neurous trans mitter

关 键 词：线粒体DNA 定量分析 衰老 

分 类 号：R339.38[医药卫生—人体生理学]