六味地黄丸治疗糖尿病合并高血压肾损害的临床观察  

Efficacy of Liuwei Dihuang Pill on the Chronic Kidney Disease Induced by Dibetes Mellitus and Hypertensive Diseases

作　　者：郑晓梅[1] 代宏勋[1] 黄宗文[2] 林火真[1] 张绍英[1] 张庆[1] 

机构地区：[1]成都市第五人民医院老年科,成都611130 [2]四川大学华西医院中西医结合科

出　　处：《华西医学》2011年第4期490-492,共3页West China Medical Journal

基　　金：成都市卫生局科研专项基金(0809)~~

摘　　要：目的探讨六味地黄丸对糖尿病合并高血压病所致慢性肾脏疾病(chronic kidney disease,CKD)患者肾损害及胰岛素抵抗的影响。方法收集2008年7月1日2010年7月1日在成都市第五人民医院住院部及门诊就诊的120例糖尿病合并高血压病患者相关资料,随机分为对照组和治疗组各60例,对照组给予西医治疗,治疗组在西医治疗的基础上加用六味地黄丸,12周为1个疗程。观察治疗前后尿白蛋白/尿肌酐(ACR),内生肌酐清除率(Ccr)及胰岛素抵抗指数(HOMA-IR)、C反应蛋白(CRP)、血脂等指标的变化。结果治疗后治疗组与对照组比较,ACR(P=0.012)、血清CRP(P=0.000)和低密度脂蛋白(P=0.014)差异有统计学意义。HOMA-IR治疗前后结果差异有统计学意义(P<0.05),但与对照组比较差异无统计学意义(P>0.05)。结论六味地黄丸可改善肾损害实验室指标,改善胰岛素抵抗,减轻体内炎性反应,改善脂代谢异常。Objective To investigate the efficacy of Liuwei Dihuang pill on patients with chronic kidney disease（CKD） induced by diabetes mellitus and hypertensive diseases in terms of renal injury and insulin resistance.Methods We collected the clinical data of 120 patients with diabetes mellitus and hypertensive diseases in the Fifth People＇s Hospital of Chengdu from July 1,2008 to July 1,2010,and randomly divided them into two groups.In the control group,patients only received therapy of western medicine,while for patients in the treatment group,Liuwei Dihuang pills were added on the basis of western medicine treatment with a treatment course of 12 weeks.Before and after the treatment,urinary albumin / urinary creatinine（ACR）,creatinine clearance rate（Ccr） and insulin resistance index（HOMA-IR）,C-reactive protein（CRP）,and lipids were evaluated and compared.Results After treatment,ACR（P=0.012）,serum CRP（P=0.000） and low-density lipoproteins（LDL）（P=0.014） for the treatment group were significantly different from those for the control group.HOMA-IR for the treatment group before and after the treatment was significantly different（P0.05）,while there was no statistical difference between the two groups in HOMA-IR（P0.05）.Conclusion Kidney-nourishing therapy with Liuwei Dihuang pill can improve the laboratory indicators of renal injury or insulin resistance,reduce the inflammatory response in vivo,and ameliorate disorders of lipid metabolism.

关 键 词：六味地黄丸 糖尿病 高血压病 慢性肾脏疾病 胰岛素抵抗 

分 类 号：R259[医药卫生—中西医结合]