血浆NGAL在创伤脓毒症诊断中的作用研究  

Plasma neutrophil gelatinase-associated lipocalin and diagnostic tool for septic complications after trauma

作　　者：韩溟[1] 林哲绚[1] 丁山[1] 

机构地区：[1]汕头大学医学院第二附属医院急诊科,广东汕头515041

出　　处：《创伤外科杂志》2011年第3期254-256,共3页Journal of Traumatic Surgery

基　　金：汕头市科技计划项目[汕府科(2008)85]资助

摘　　要：目的探讨血浆中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase-associatedlipocalin，NGAL）在创伤合并脓毒症诊断中的意义。方法2007年6月-2010年6月就诊的81例创伤病人。人院当时以及12、24、48小时采血，ELISA法检测血浆NGAL浓度。测定入院时血液白细胞计数。结果2l例创伤合并脓毒症患者血浆NGAL水平显著高于无合并脓毒症患者（P〈0．05）。以48小时内NGAL峰值绘制ROC曲线，曲线下面积为0．7198（P=0．0011）。入院时血浆NGAL水平与白细胞计数呈正相关。结论血浆NGAL浓度在一定程度上可鉴别患者是否合并脓毒症，可用于临床辅助诊断。Objective To investigate the diagnostic value of neutrophil gelatinase - associated lipocalin （ NGAL} in septic complications after trauma. Methods Totally 81 patients with trauma were reviewed,who were admitted to the emergency department of Second Affiliated Hospital, Medical College of Shantou University,between Apr. 2007 and Apr. 2010. Plasma was collected at admission, 12, 24 and 48 hours to measure plasma NGAL by ELISA. Results Totally 21 patients with septic trauma had much higher plasma NGAL concentration （ P 〈 0.05 ）. The areas under the curve in the diagnosis of sepsis were 0. 7198 （ P = 0. 0011 }. Plasma NGAL at than patients without sepsis admission showed a positive correlation with white cell count. Conclusion High NGAL concentra- tion after trauma indicates an increased risk of septic complications.

关 键 词：创伤 脓毒症 中性粒细胞明胶酶相关脂质运载蛋白 

分 类 号：R64[医药卫生—外科学]