重组人生长激素治疗肝硬化低蛋白血症的影响因素及意义  

Therapeutic effect of recombinant human growth hormone in the treatment of liver cirrhosis with different levels of hypoproteinemia

作　　者：周梅花[1] 孙大勇[1] 赵亚刚[1] 宋鸿[1] 王卫卫[1] 周兰[1] 

机构地区：[1]广州军区广州总医院消化内科,510010

出　　处：《现代消化及介入诊疗》2011年第2期87-89,共3页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的探讨重组人生长激素对不同血清白蛋白含量肝硬化患者低蛋白血症的临床疗效及意义。方法将92例血清白蛋白含量低于35g/L的肝硬化患者根据血清白蛋白含量分为3组:轻度低水平组(30.0～35.0g/L)、中度低水平组(25.0～30.0g/L)、重度低水平组(20.0～25.0g/L),每组随机分为两组,治疗组给予重组人生长激素4IU肌注,1次/2日;对照组给予20%人血白蛋白100ml静滴,1次/2日,两组疗程均为30d。治疗组和对照组均给予相同方案的保肝、对症治疗。分别于治疗后15d、30d、60d、90d测定相应观察指标。结果治疗后30d两组患者血清白蛋白含量均上升,治疗组于治疗后第90d后仍维持高点水平,且肝功能好转,而对照组60d后白蛋白含量开始降低;血清白蛋白浓度大于25.0g/L时,治疗组观察指标改善尤为明显。结论重组人生长激素可明显提高肝硬化低蛋白血症患者血清白蛋白水平,中远期疗效好,并可改善肝功能;肝硬化患者血清白蛋白浓度对生长激素的疗效具有显著影响。Objective To investigate the therapeutic effect of recombinant human growth hormone （rhGH） in the treatment of liver cirrhosis with different levels of hypoproteinemia.Methods Ninety-two patients with liver cirrhosis and low serum albumin were divided to three groups on the basis of different levels of hypoproteinemia.Patients in each group were randomly assigned to receive intramuscular injection of 4 IU rhGH （treatment group） or intravenous injection of 100 ml 20% human serum albumin （control group） once every 2 days for 30 days.Both groups received hepatoprotective and symptomatic treaments.Contents of albumin and other items were measured at day 15,30,60,and 90 after treatment.Results Serum albumin was increased in both groups at day 30.In contrast,serum albumin and hepatic function of patients in treatment group were much better than in control group at day 90.The therapeutic effect of rhGH was much better in patients with serum albumin above 25.0 g/L than below it.Conclusion Recombinant human growth hormone can increase the level of serum albumin and improve hepatic function of patients with liver cirrhosis,and has a longterm curative effect.In addition,the therapeutic effect is closely related to the level of hypoproteinemia.

关 键 词：生长激素 肝硬化 低蛋白血症 

分 类 号：R644[医药卫生—外科学]