交联共聚淀粉微球对阿司匹林吸附性能的研究  

A Study on Adsorption Behaviors of Crosslinking Starch Microspheres for Aspirin

作　　者：姚少芳[1] 赵新法[1] 

机构地区：[1]陕西能源职业技术学院,陕西咸阳712000

出　　处：《贵阳医学院学报》2011年第2期124-127,131,共5页Journal of Guiyang Medical College

基　　金：国家自然科学基金资助项目(50573046);陕西省教育厅产业化培育项目(02JC05)

摘　　要：目的:研究交联淀粉微球CSMs对阿司匹林的吸附性能,探讨引发剂用量、交联剂用量、反应温度和反应时间等因素对吸附量的影响规律。方法:以可溶性淀粉为原料,K2S2O8-Na2SO3为引发剂,N,N′-亚甲基双丙烯酰胺为交联剂,在反相悬浮体系中合成交联共聚淀粉微球CSMs;以CSMs为吸附载体,在阿司匹林乙醇溶液中进行吸附实验,测定相关参数。结果:引发剂用量为3 g/L时,CSMs对阿司匹林的吸附量达到180 mg/g;交联剂用量和添加方式在很大程度上决定了CSMs对阿司匹林的吸附和缓释性能;在一定温度范围内,温度升高,CSMs对阿司匹林的吸附量显著增大;反应初期,CSMs对阿司匹林的吸附量随反应时间的增加而急剧增加,在1.5 h后趋于和缓。结论:CSMs对阿司匹林有较高的载药量和包封率,可作为阿司匹林的吸附载体。Objective： To study the adsorbability of crosslinking starch microspheres（CSMs） for aspirin,and to explore the influence regularity of factors such as dosages of initiator and crosslinking agent,temperature and time needed for reaction on adsorption quantity.Methods： CSMs microspheres were synthetized in reversed-phase suspension system with soluble starch as raw materials,K2S2O8-Na2SO3 as initiator,and N,N′-methylene acrylamide as crosslinking agent.The adsorption experiments were carried out in aspirin ethanol solution using CSMs as carrier.Correlated parameters were detected.Results： The adsorption quantity of aspirin to CSMs reached 180mg/g when initiator agent dosage was 3 g/L.The adsorption and sustained release behaviors depended mainly on the dosage and adding method of crosslinking agent.The adsorption quantity increased significantly with increasing reaction temperature in a certain range.In the initial reaction stage,the adsorption quantity increased significantly with increase of reaction time and went to gentle in one and half hours later.CSMs may be used as one of drug carriers for aspirin due to its excellent drug loading quantity and embedding ratio.Conclusions： CSMs shows a favourable adsorption performance for aspirin.

关 键 词：淀粉微球 交联 N N′-亚甲基双丙烯酰胺 阿司匹林 吸附 

分 类 号：O63[理学—高分子化学] R318[理学—化学]