来宾市艾滋病分子流行病学调查  

AIDS molecular epidemiological survey in Laibin

作　　者：周方 骆安德 蒋就喜[2] 陶田秀 黄甲清[4] 胡婷婷[5] 李赫伟[2] 

机构地区：[1]来宾市人民医院,广西来宾546100 [2]桂林医学院附属医院感染性疾病科,广西桂林541001 [3]云浮市人民医院,广东云浮527300 [4]广西医科大学科研处,广西南宁530021 [5]桂林医学院生物技术学院,广西桂林541004

出　　处：《热带医学杂志》2011年第4期420-423,共4页Journal of Tropical Medicine

基　　金：广西自然科学基金(0640192);广西教育厅科研基金(桂教科研[2007]34号);广西本级技术研究与开发项目(桂财教[2010]124号);广西医疗卫生重点科研课题(重2010055);桂林市科学研究与技术开发项目(市科[2010]37号)

摘　　要：目的对来宾市HIV-1感染者进行分子流行病学调查,为来宾市艾滋病的防治工作提供实验依据。方法将流行病学方法与分子生物学方法相结合,对来宾市HIV株进行序列测定和亚型分析,总结其传播途径,分析流行毒株特点及各个流行毒株间的关系。结果来宾市HIV感染者以性传播为主,流行毒株存在B、01-AE、CRF-BC3种亚型,其中以CRF-BC流行毒株为主。结论来宾市艾滋病流行形势严峻,HIV-1感染者中以流行重组型亚型CRF-BC为主,应加强对HIV-1毒株亚型变异的监测,积极进行行为干预,及时制定新的防治策略。Objective To make the molecular epidemiological survey on the populations affected with HIV-1 to provide experimental basis for prevention and control of AIDS in Laibin.Methods Combined epidemiological methods with molecular biological methods,the AIDS strains in Laibin were sequenced and its subtype was analyzed.Meanwhile,the way of transmission and the relationship between the characteristics of the epidemiological strains and the various strains of AIDS were analyzed.Result The main transmission way of AIDS is through sex in Laibin among the infected populations,with the epidemical strains B,01-AE,and CRF-BC subtypes,in which CRF-BC strain was the major one.Conclusions AIDS epidemic situation becomes critical in Laibin,and the main subtype is epidemiological reconstruction-type CRF-BC in HIV-1 affected populations,so we should strengthen the monitor of the variation of HIV-1 subtype strains,actively conduct behavioral intervention and make new prevention and therapy strategy timely.

关 键 词：分子流行病学 HIV-1 亚型 巢氏PCR 

分 类 号：R512.91[医药卫生—内科学]